DegronMD - Q5THJ4(VPS13D)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S2079F	TCGA-21-5783	LUSC	TCGA	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation blocking phosphorylation signal	0.75
p.S2079F	DO27437	LUSC	ICGC	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation blocking phosphorylation signal	0.75
p.S2127F	TCGA-55-7283	LUAD	TCGA	VPSTS	DEG_SPOP_SBC_1	2123:2127	Mutation altering degron motif	0.7982
p.S2127F	DO23606	LUAD	ICGC	VPSTS	DEG_SPOP_SBC_1	2123:2127	Mutation altering degron motif	0.7982
p.C3146F	TCGA-60-2710	LUSC	TCGA	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation rewiring degron network	0.2222
p.C3146F	TCGA-98-A538	LUSC	TCGA	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation rewiring degron network	0.2222
p.N3161S	TCGA-76-6283	GBM	TCGA	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation rewiring degron network	0.1389
p.N3161S	DO223727	GBM	ICGC	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation rewiring degron network	0.1389
p.E1590A	TCGA-A5-A0G2	UCEC	TCGA	RKENG	DEG_APCC_KENBOX_2	1588:1592	Mutation altering degron motif	0.7701
p.E1590A	DO41235	UCEC	ICGC	RKENG	DEG_APCC_KENBOX_2	1588:1592	Mutation altering degron motif	0.7701
p.S2074Y	TCGA-A5-A1OF	UCEC	TCGA	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation altering degron motif	0.6009
p.S2074Y	DO42568	UCEC	ICGC	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation altering degron motif	0.6009
p.P2076S	TCGA-AA-3966	COAD	TCGA	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation altering degron motif	0.6752
p.P2076S	DO10068	COAD	ICGC	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation altering degron motif	0.6752
p.T3653A	TCGA-AP-A056	UCEC	TCGA	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.2778
p.T3653A	TCGA-XJ-A9DX	PRAD	TCGA	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.2778
p.T3653A	DO51402	PRAD	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.2778
p.T3653A	DO43971	UCEC	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.2778
p.S1598I	TCGA-AP-A0LM	UCEC	TCGA	RKENG	DEG_APCC_KENBOX_2	1588:1592	Mutation blocking phosphorylation signal	0.6111
p.S1598I	DO43306	UCEC	ICGC	RKENG	DEG_APCC_KENBOX_2	1588:1592	Mutation blocking phosphorylation signal	0.6111
p.G2065D	TCGA-AX-A3FT	UCEC	TCGA	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation rewiring degron network	0.25
p.G2065D	DO40801	UCEC	ICGC	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation rewiring degron network	0.25
p.A773V	TCGA-B5-A3FA	UCEC	TCGA	PLATPPNT	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.5825
p.A773V	DO52402	UCEC	ICGC	PLATPPNT	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.5825
p.E3152D	TCGA-BK-A6W3	UCEC	TCGA	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation altering degron motif	0.6758
p.E3152D	TCGA-D1-A17Q	UCEC	TCGA	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation altering degron motif	0.6758
p.E3152D	TCGA-EY-A1G8	UCEC	TCGA	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation altering degron motif	0.6758
p.E3152D	DO50076	UCEC	ICGC	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation altering degron motif	0.6758
p.E3152D	DO43578	UCEC	ICGC	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation altering degron motif	0.6758
p.E3152D	DO41903	UCEC	ICGC	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation altering degron motif	0.6758
p.R3644C	TCGA-CM-4744	COAD	TCGA	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation altering degron motif	0.8301
p.R3644C	DO8882	COAD	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation altering degron motif	0.8301
p.L1593V	TCGA-EB-A431	SKCM	TCGA	RKENG	DEG_APCC_KENBOX_2	1588:1592	Mutation rewiring degron network	0.3056
p.L1593V	DO37671	SKCM	ICGC	RKENG	DEG_APCC_KENBOX_2	1588:1592	Mutation rewiring degron network	0.3056
p.T1602N	TCGA-EI-6881	READ	TCGA	RKENG	DEG_APCC_KENBOX_2	1588:1592	Mutation rewiring degron network	0.0556
p.T1602N	DO37098	READ	ICGC	RKENG	DEG_APCC_KENBOX_2	1588:1592	Mutation rewiring degron network	0.0556
p.P1759L	TCGA-ER-A199	SKCM	TCGA	PLTPPPS	DEG_SCF_FBW7_1	1759:1765	Mutation altering degron motif	0.6471
p.P1759L	DO47395	SKCM	ICGC	PLTPPPS	DEG_SCF_FBW7_1	1759:1765	Mutation altering degron motif	0.6471
p.G2116R	TCGA-G4-6588	COAD	TCGA	VPSTS	DEG_SPOP_SBC_1	2123:2127	Mutation rewiring degron network	0.1389
p.G2116R	DO10140	COAD	ICGC	VPSTS	DEG_SPOP_SBC_1	2123:2127	Mutation rewiring degron network	0.1389
p.M3650T	DO222454	BTCA	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation altering degron motif	0.7423
p.A208V	DO8447	COAD	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6936
p.P218L	DO234173	ESAD	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0556
p.P2133L	DO228615	GACA	ICGC	VPSTS	DEG_SPOP_SBC_1	2123:2127	Mutation rewiring degron network	0.1667
p.R3649H	DO233206	GACA	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation altering degron motif	0.7133
p.E767K	DO11854	GBM	ICGC	PLATPPNT	DEG_SCF_FBW7_1	771:778	Mutation rewiring degron network	0.2222
p.E767K	DO11854	GBM	ICGC	PPNTPPPE	DEG_SCF_FBW7_2	775:782	Mutation rewiring degron network	0.1111
p.A202S	DO228952	LICA	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.3056
p.S1579I	DO228986	LICA	ICGC	RKENG	DEG_APCC_KENBOX_2	1588:1592	Mutation rewiring degron network	0.0833
p.G3654V	DO229018	LICA	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.25
p.R194L	DO229022	LICA	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.Q207H	DO229027	LICA	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7582
p.G3653V	DO229009	LICA	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.2778
p.A3648V	DO23846	LUAD	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation altering degron motif	0.6936
p.R210K	DO26508	LUSC	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2778
p.S2068F	DO220881	MELA	ICGC	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation altering degron motif	0.7982
p.E3652K	DO222521	MELA	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.3056
p.A198S	DO50726	ORCA	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.L199P	DO219881	SKCA	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.P771L	DO229459	SKCA	ICGC	PLATPPNT	DEG_SCF_FBW7_1	771:778	Mutation altering degron motif	0.6471
p.L215V	DO229456	SKCA	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389
p.A213T	DO37782	SKCM	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.P3642L	DO219501	SKCM	ICGC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.3056
p.S216G	DO229253	THCA	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.G217C	DO229211	THCA	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.G217S	DO41331	UCEC	ICGC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.T3653I	SIDM00683	Prostate Carcinoma	GDSC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.2778
p.T3653I	ACH-000977	lymph node	CCLE	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.2778
p.T3653I	LNCaP-Clone-FGC	prostate	COSMIC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.2778
p.P1766S	SIDM00545	Melanoma	GDSC	PLTPPPS	DEG_SCF_FBW7_1	1759:1765	Mutation rewiring degron network	0.3056
p.P1766S	ACH-000987	Skin Cancer	CCLE	PLTPPPS	DEG_SCF_FBW7_1	1759:1765	Mutation rewiring degron network	0.3056
p.P1766S	Mewo	skin	COSMIC	PLTPPPS	DEG_SCF_FBW7_1	1759:1765	Mutation rewiring degron network	0.3056
p.G3652E	SIDM00545	Melanoma	GDSC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.3056
p.G3652E	ACH-000987	Skin Cancer	CCLE	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.3056
p.G3652E	Mewo	skin	COSMIC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.3056
p.I205V	SIDM01023	Acute Myeloid Leukemia	GDSC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.5965
p.I205V	SIDM00082	Melanoma	GDSC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.5965
p.I205V	SIDM00482	Chronic Myelogenous Leukemia	GDSC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.5965
p.I205V	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.5965
p.I205V	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.5965
p.P3159H	SIDM01090	Colorectal Carcinoma	GDSC	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation rewiring degron network	0.1944
p.P3159H	ACH-000943	Colon/Colorectal Cancer	CCLE	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation rewiring degron network	0.1944
p.P3159H	RKO	large intestine	COSMIC	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation rewiring degron network	0.1944
p.T1767I	SIDM00600	Thyroid Gland Carcinoma	GDSC	PLTPPPS	DEG_SCF_FBW7_1	1759:1765	Mutation blocking phosphorylation signal	0.7222
p.T1767I	SIDM00243	Other Solid Cancers	GDSC	PLTPPPS	DEG_SCF_FBW7_1	1759:1765	Mutation blocking phosphorylation signal	0.7222
p.G215R	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389
p.G215R	ACH-000860	Lung Cancer	CCLE	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389
p.G215R	NCI-H358	lung	COSMIC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389
p.G788R	SIDM00889	Cervical Carcinoma	GDSC	SSSNGE	DEG_Kelch_Keap1_1	784:789	Mutation altering degron motif	0.7568
p.G788R	ACH-001333	Cervical Cancer	CCLE	SSSNGE	DEG_Kelch_Keap1_1	784:789	Mutation altering degron motif	0.7568
p.G788R	C-33-A	cervix	COSMIC	SSSNGE	DEG_Kelch_Keap1_1	784:789	Mutation altering degron motif	0.7568
p.I1773L	SIDM00865	Small Cell Lung Carcinoma	GDSC	PLTPPPS	DEG_SCF_FBW7_1	1759:1765	Mutation rewiring degron network	0.1111
p.I1773L	ACH-000530	Lung Cancer	CCLE	PLTPPPS	DEG_SCF_FBW7_1	1759:1765	Mutation rewiring degron network	0.1111
p.I1773L	DMS-114	lung	COSMIC	PLTPPPS	DEG_SCF_FBW7_1	1759:1765	Mutation rewiring degron network	0.1111
p.H3658Y	SIDM00927	Small Cell Lung Carcinoma	GDSC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.1389
p.H3658Y	ACH-000871	Lung Cancer	CCLE	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.1389
p.H3658Y	NCI-H510A	lung	COSMIC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.1389
p.T2136A	SIDM00814	Other Solid Cancers	GDSC	VPSTS	DEG_SPOP_SBC_1	2123:2127	Mutation rewiring degron network	0.0833
p.F2067C	SIDM00850	Gastric Carcinoma	GDSC	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation rewiring degron network	0.3056
p.F2067C	ACH-000880	Gastric Cancer	CCLE	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation rewiring degron network	0.3056
p.F2067C	AGS	stomach	COSMIC	SLQDKESVPSA	DEG_COP1_1	2068:2078	Mutation rewiring degron network	0.3056
p.I205M	SIDM00937	Oral Cavity Carcinoma	GDSC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6507
p.I205M	CAL-27	upper aerodigestive tract	COSMIC	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6507
p.D216N	ACH-000982	Colon/Colorectal Cancer	CCLE	FSIYWD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.P1763S	ACH-002669	Colon/Colorectal Cancer	CCLE	PLTPPPS	DEG_SCF_FBW7_1	1759:1765	Mutation altering degron motif	0.5641
p.H3633Y	NCI-H510A	lung	COSMIC	KRSQLWRMT	DEG_APCC_DBOX_1	3643:3651	Mutation rewiring degron network	0.0556
p.Q3148H	HCT-15	large intestine	COSMIC	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation rewiring degron network	0.2778
p.L3164S	SNU-1040	large intestine	COSMIC	KKENY	DEG_APCC_KENBOX_2	3150:3154	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VPS13D

UniProt ID: Q5THJ4

Entrez ID: 55187

Protein name: Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VPS13D in