DegronMD

Uniprot ID: Q5THJ4

Source protein: Intermembrane lipid transfer protein VPS13D

Source gene: VPS13D

Class: DEG_Kelch_Keap1_1

Location: 784:789

E3 ligase: KEAP1

DEGRON score: 0.9085

ASA_SCORE: 80.95

COIL: 0.9188

CONS_SCORE: 0.245

DSS_SCORE: 0.8069

HELIX: 0.0523

FCONS_SCORE: 0.8993

RIG_SCORE: 0.4727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G788R	SIDM00889	Cervical Carcinoma	GDSC	SSSNGE	DEG_Kelch_Keap1_1	0.7568
p.G788R	ACH-001333	Cervical Cancer	CCLE	SSSNGE	DEG_Kelch_Keap1_1	0.7568
p.G788R	C-33-A	cervix	COSMIC	SSSNGE	DEG_Kelch_Keap1_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_Kelch_Keap1_1	784:789	SSSNGE	KEAP1	0.9085	More...
Q9BZ72	Membrane-associated phosphatidylinositol transfer protein 2	DEG_Kelch_Keap1_1	288:293	SSSNGE	KEAP1	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons