DegronMD

Uniprot ID: Q9BZ72

Source protein: Membrane-associated phosphatidylinositol transfer protein 2

Source gene: PITPNM2

Class: DEG_Kelch_Keap1_1

Location: 288:293

E3 ligase: KEAP1

DEGRON score: 0.9948

ASA_SCORE: 76.15

COIL: 0.8823

CONS_SCORE: 0.3638

DSS_SCORE: 0.825

HELIX: 0.0768

FCONS_SCORE: 1.0898

RIG_SCORE: 0.5399

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S289R	TCGA-14-1795	GBM	TCGA	SSSNGE	DEG_Kelch_Keap1_1	0.6316
p.S289R	DO13114	GBM	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.6316
p.P285L	TCGA-AA-3864	COAD	TCGA	SSSNGE	DEG_Kelch_Keap1_1	0.25
p.P285L	DO8490	COAD	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.25
p.K301N	TCGA-AX-A0J0	UCEC	TCGA	SSSNGE	DEG_Kelch_Keap1_1	0.2222
p.K301N	DO41133	UCEC	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.2222
p.R298C	TCGA-CK-4951	COAD	TCGA	SSSNGE	DEG_Kelch_Keap1_1	0.1944
p.R298C	DO10582	COAD	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.1944
p.R298C	DO230315	COCA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.1944
p.R298C	SIDM01023	Acute Myeloid Leukemia	GDSC	SSSNGE	DEG_Kelch_Keap1_1	0.1944
p.R298C	SIDM01608	Endometrial Carcinoma	GDSC	SSSNGE	DEG_Kelch_Keap1_1	0.1944
p.S288G	TCGA-DI-A1BU	UCEC	TCGA	SSSNGE	DEG_Kelch_Keap1_1	0.6993
p.S288G	DO42023	UCEC	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.6993
p.G297W	TCGA-FS-A1ZP	SKCM	TCGA	SSSNGE	DEG_Kelch_Keap1_1	0.2222
p.G297W	DO37703	SKCM	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.2222
p.G282V	TCGA-IN-A6RL	STAD	TCGA	SSSNGE	DEG_Kelch_Keap1_1	0.1667
p.G282V	DO51738	STAD	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.1667
p.G292W	DO225273	BRCA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.7825
p.G280V	DO222864	COCA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.1111
p.Q279K	DO229019	LICA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.0833
p.P298T	DO229028	LICA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.1944
p.R298H	DO35100	PACA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.1944
p.R298H	SIDM00338	Acute Myeloid Leukemia	GDSC	SSSNGE	DEG_Kelch_Keap1_1	0.1944
p.R298H	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	SSSNGE	DEG_Kelch_Keap1_1	0.1944
p.L292M	DO42280	UCEC	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.711
p.G285D	DO42977	UCEC	ICGC	SSSNGE	DEG_Kelch_Keap1_1	0.25
p.L300F	SIDM00721	Small Cell Lung Carcinoma	GDSC	SSSNGE	DEG_Kelch_Keap1_1	0.1389
p.L300F	ACH-002171	Lung Cancer	CCLE	SSSNGE	DEG_Kelch_Keap1_1	0.1389
p.L300F	NCI-H250	lung	COSMIC	SSSNGE	DEG_Kelch_Keap1_1	0.1389
p.P294S	SIDM01770	Gastric Carcinoma	GDSC	SSSNGE	DEG_Kelch_Keap1_1	0.3056
p.P294S	ACH-000908	Gastric Cancer	CCLE	SSSNGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_Kelch_Keap1_1	784:789	SSSNGE	KEAP1	0.9085	More...
Q9BZ72	Membrane-associated phosphatidylinositol transfer protein 2	DEG_Kelch_Keap1_1	288:293	SSSNGE	KEAP1	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSSNGE

Degron related mutations and impact score

Drug responses associated with PITPNM2 mutations

All proteins holding degron of SSSNGE