DegronMD - Q9BZ72(PITPNM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S289R	TCGA-14-1795	GBM	TCGA	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation altering degron motif	0.6316
p.S289R	DO13114	GBM	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation altering degron motif	0.6316
p.P285L	TCGA-AA-3864	COAD	TCGA	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.25
p.P285L	DO8490	COAD	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.25
p.K301N	TCGA-AX-A0J0	UCEC	TCGA	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation substituting flanking lysine	0.2222
p.K301N	DO41133	UCEC	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation substituting flanking lysine	0.2222
p.D860Y	TCGA-BC-A10Z	LIHC	TCGA	RRLSLLALP	DEG_APCC_DBOX_1	869:877	Mutation rewiring degron network	0.0833
p.D860Y	DO23043	LIHC	ICGC	RRLSLLALP	DEG_APCC_DBOX_1	869:877	Mutation rewiring degron network	0.0833
p.R298C	TCGA-CK-4951	COAD	TCGA	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1944
p.R298C	DO10582	COAD	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1944
p.R298C	DO230315	COCA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1944
p.R298C	SIDM01023	Acute Myeloid Leukemia	GDSC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1944
p.R298C	SIDM01608	Endometrial Carcinoma	GDSC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1944
p.S288G	TCGA-DI-A1BU	UCEC	TCGA	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation altering degron motif	0.6993
p.S288G	DO42023	UCEC	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation altering degron motif	0.6993
p.G297W	TCGA-FS-A1ZP	SKCM	TCGA	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.2222
p.G297W	DO37703	SKCM	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.2222
p.G282V	TCGA-IN-A6RL	STAD	TCGA	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1667
p.G282V	DO51738	STAD	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1667
p.R870H	TCGA-NH-A5IV	COAD	TCGA	RRLSLLALP	DEG_APCC_DBOX_1	869:877	Mutation altering degron motif	0.8244
p.R870H	DO49095	COAD	ICGC	RRLSLLALP	DEG_APCC_DBOX_1	869:877	Mutation altering degron motif	0.8244
p.T883P	DO217788	BRCA	ICGC	RRLSLLALP	DEG_APCC_DBOX_1	869:877	Mutation rewiring degron network	0.1667
p.G292W	DO225273	BRCA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation altering degron motif	0.7825
p.G280V	DO222864	COCA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1111
p.Q279K	DO229019	LICA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.0833
p.P298T	DO229028	LICA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1944
p.R298H	DO35100	PACA	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1944
p.R298H	SIDM00338	Acute Myeloid Leukemia	GDSC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1944
p.R298H	ME-1	haematopoietic and lymphoid tissue	COSMIC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1944
p.P859S	DO35723	PBCA	ICGC	RRLSLLALP	DEG_APCC_DBOX_1	869:877	Mutation rewiring degron network	0.0556
p.T882P	DO229257	THCA	ICGC	RRLSLLALP	DEG_APCC_DBOX_1	869:877	Mutation rewiring degron network	0.1944
p.L292M	DO42280	UCEC	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation altering degron motif	0.711
p.G285D	DO42977	UCEC	ICGC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.25
p.L300F	SIDM00721	Small Cell Lung Carcinoma	GDSC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1389
p.L300F	ACH-002171	Lung Cancer	CCLE	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1389
p.L300F	NCI-H250	lung	COSMIC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.1389
p.P294S	SIDM01770	Gastric Carcinoma	GDSC	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.3056
p.P294S	ACH-000908	Gastric Cancer	CCLE	SSSNGE	DEG_Kelch_Keap1_1	288:293	Mutation rewiring degron network	0.3056
p.D860N	ACH-000972	Endometrial/Uterine Cancer	CCLE	RRLSLLALP	DEG_APCC_DBOX_1	869:877	Mutation rewiring degron network	0.0833
p.P869L	NCI-H1693	lung	COSMIC	RRLSLLALP	DEG_APCC_DBOX_1	869:877	Mutation altering degron motif	0.7582

Kaplan plot for PITPNM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PITPNM2

UniProt ID: Q9BZ72

Entrez ID: 57605

Protein name: Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PITPNM2 in