DegronMD

Uniprot ID: Q9BZ72

Source protein: Membrane-associated phosphatidylinositol transfer protein 2

Source gene: PITPNM2

Class: DEG_APCC_DBOX_1

Location: 869:877

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.962

ASA_SCORE: 92.2

COIL: 0.5812

CONS_SCORE: 0.3172

DSS_SCORE: 0.5912

HELIX: 0.3787

FCONS_SCORE: 1.0697

RIG_SCORE: 0.6933

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D860Y	TCGA-BC-A10Z	LIHC	TCGA	RRLSLLALP	DEG_APCC_DBOX_1	0.0833
p.D860Y	DO23043	LIHC	ICGC	RRLSLLALP	DEG_APCC_DBOX_1	0.0833
p.R870H	TCGA-NH-A5IV	COAD	TCGA	RRLSLLALP	DEG_APCC_DBOX_1	0.8244
p.R870H	DO49095	COAD	ICGC	RRLSLLALP	DEG_APCC_DBOX_1	0.8244
p.T883P	DO217788	BRCA	ICGC	RRLSLLALP	DEG_APCC_DBOX_1	0.1667
p.P859S	DO35723	PBCA	ICGC	RRLSLLALP	DEG_APCC_DBOX_1	0.0556
p.T882P	DO229257	THCA	ICGC	RRLSLLALP	DEG_APCC_DBOX_1	0.1944
p.D860N	ACH-000972	Endometrial/Uterine Cancer	CCLE	RRLSLLALP	DEG_APCC_DBOX_1	0.0833
p.P869L	NCI-H1693	lung	COSMIC	RRLSLLALP	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZ72	Membrane-associated phosphatidylinositol transfer protein 2	DEG_APCC_DBOX_1	869:877	RRLSLLALP	APC,CDC20,FZR1	0.962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons