DegronMD

Uniprot ID: Q5THJ4

Source protein: Intermembrane lipid transfer protein VPS13D

Source gene: VPS13D

Class: DEG_APCC_KENBOX_2

Location: 1588:1592

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.732

ASA_SCORE: 95.52

COIL: 0.6156

CONS_SCORE: 0.2696

DSS_SCORE: 0.489

HELIX: 0.2588

FCONS_SCORE: 1.0233

RIG_SCORE: 0.6647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1590A	TCGA-A5-A0G2	UCEC	TCGA	RKENG	DEG_APCC_KENBOX_2	0.7701
p.E1590A	DO41235	UCEC	ICGC	RKENG	DEG_APCC_KENBOX_2	0.7701
p.S1598I	TCGA-AP-A0LM	UCEC	TCGA	RKENG	DEG_APCC_KENBOX_2	0.6111
p.S1598I	DO43306	UCEC	ICGC	RKENG	DEG_APCC_KENBOX_2	0.6111
p.L1593V	TCGA-EB-A431	SKCM	TCGA	RKENG	DEG_APCC_KENBOX_2	0.3056
p.L1593V	DO37671	SKCM	ICGC	RKENG	DEG_APCC_KENBOX_2	0.3056
p.T1602N	TCGA-EI-6881	READ	TCGA	RKENG	DEG_APCC_KENBOX_2	0.0556
p.T1602N	DO37098	READ	ICGC	RKENG	DEG_APCC_KENBOX_2	0.0556
p.S1579I	DO228986	LICA	ICGC	RKENG	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	114:118	RKENG	APC,CDC20,FZR1	0.7661	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_APCC_KENBOX_2	1588:1592	RKENG	APC,CDC20,FZR1	0.732	More...
Q8TCS8	Polyribonucleotide nucleotidyltransferase 1, mitochondrial	DEG_APCC_KENBOX_2	600:604	RKENG	APC,CDC20,FZR1	0.6929	More...
Q96JQ2	Calmin	DEG_APCC_KENBOX_2	411:415	RKENG	APC,CDC20,FZR1	0.9146	More...
Q5T3I0	G patch domain-containing protein 4	DEG_APCC_KENBOX_2	32:36	RKENG	APC,CDC20,FZR1	0.8966	More...
A8MTL3	RING finger protein 212B	DEG_APCC_KENBOX_2	121:125	RKENG	APC,CDC20,FZR1	0.5043	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons