DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RKENG
Uniprot ID:
A8MTL3
Source protein:
RING finger protein 212B
Source gene:
RNF212B
Class:
DEG_APCC_KENBOX_2
Location:
121:125
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5043
ASA_SCORE:
100.62
COIL:
0.021
CONS_SCORE:
0.5854
DSS_SCORE:
0.26
HELIX:
0.9796
FCONS_SCORE:
1.1766
RIG_SCORE:
0.7601
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RNF212B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RKENG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13625
Apoptosis-stimulating of p53 protein 2
DEG_APCC_KENBOX_2
114:118
RKENG
APC,CDC20,FZR1
0.7661
More...
Q5THJ4
Intermembrane lipid transfer protein VPS13D
DEG_APCC_KENBOX_2
1588:1592
RKENG
APC,CDC20,FZR1
0.732
More...
Q8TCS8
Polyribonucleotide nucleotidyltransferase 1, mitochondrial
DEG_APCC_KENBOX_2
600:604
RKENG
APC,CDC20,FZR1
0.6929
More...
Q96JQ2
Calmin
DEG_APCC_KENBOX_2
411:415
RKENG
APC,CDC20,FZR1
0.9146
More...
Q5T3I0
G patch domain-containing protein 4
DEG_APCC_KENBOX_2
32:36
RKENG
APC,CDC20,FZR1
0.8966
More...
A8MTL3
RING finger protein 212B
DEG_APCC_KENBOX_2
121:125
RKENG
APC,CDC20,FZR1
0.5043
More...