DegronMD - Q5T3I0(GPATCH4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A45V	TCGA-2W-A8YY	CESC	TCGA	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.0833
p.Q23K	TCGA-VQ-A8DT	STAD	TCGA	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.0833
p.I42M	TCGA-VS-A958	CESC	TCGA	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.1667
p.I37M	DO225028	BRCA	ICGC	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.3056
p.I37M	DO51639	CESC	ICGC	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.3056
p.A40V	DO223732	CESC	ICGC	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.2222
p.G31S	DO229039	LICA	ICGC	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.3056
p.L30R	DO231835	LINC	ICGC	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.2778
p.R37W	SIDM01451	Pancreatic Carcinoma	GDSC	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.3056
p.R37W	ACH-000933	Pancreatic Cancer	CCLE	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.3056
p.R37W	ACH-001540	Liposarcoma	CCLE	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.3056
p.N40D	ACH-000074	Leukemia	CCLE	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.2222
p.N40D	KU812	haematopoietic and lymphoid tissue	COSMIC	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation rewiring degron network	0.2222
p.N35D	KU812	haematopoietic and lymphoid tissue	COSMIC	RKENG	DEG_APCC_KENBOX_2	32:36	Mutation altering degron motif	0.6932

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons