DegronMD

Uniprot ID: Q5T3I0

Source protein: G patch domain-containing protein 4

Source gene: GPATCH4

Class: DEG_APCC_KENBOX_2

Location: 32:36

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8966

ASA_SCORE: 102.22

COIL: 0.818

CONS_SCORE: 0.6504

DSS_SCORE: 0.4737

HELIX: 0.0752

FCONS_SCORE: 0.9596

RIG_SCORE: 0.7191

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A45V	TCGA-2W-A8YY	CESC	TCGA	RKENG	DEG_APCC_KENBOX_2	0.0833
p.Q23K	TCGA-VQ-A8DT	STAD	TCGA	RKENG	DEG_APCC_KENBOX_2	0.0833
p.I42M	TCGA-VS-A958	CESC	TCGA	RKENG	DEG_APCC_KENBOX_2	0.1667
p.I37M	DO225028	BRCA	ICGC	RKENG	DEG_APCC_KENBOX_2	0.3056
p.I37M	DO51639	CESC	ICGC	RKENG	DEG_APCC_KENBOX_2	0.3056
p.A40V	DO223732	CESC	ICGC	RKENG	DEG_APCC_KENBOX_2	0.2222
p.G31S	DO229039	LICA	ICGC	RKENG	DEG_APCC_KENBOX_2	0.3056
p.L30R	DO231835	LINC	ICGC	RKENG	DEG_APCC_KENBOX_2	0.2778
p.R37W	SIDM01451	Pancreatic Carcinoma	GDSC	RKENG	DEG_APCC_KENBOX_2	0.3056
p.R37W	ACH-000933	Pancreatic Cancer	CCLE	RKENG	DEG_APCC_KENBOX_2	0.3056
p.R37W	ACH-001540	Liposarcoma	CCLE	RKENG	DEG_APCC_KENBOX_2	0.3056
p.N40D	ACH-000074	Leukemia	CCLE	RKENG	DEG_APCC_KENBOX_2	0.2222
p.N40D	KU812	haematopoietic_and_lymphoid_tissue	COSMIC	RKENG	DEG_APCC_KENBOX_2	0.2222
p.N35D	KU812	haematopoietic_and_lymphoid_tissue	COSMIC	RKENG	DEG_APCC_KENBOX_2	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	114:118	RKENG	APC,CDC20,FZR1	0.7661	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_APCC_KENBOX_2	1588:1592	RKENG	APC,CDC20,FZR1	0.732	More...
Q8TCS8	Polyribonucleotide nucleotidyltransferase 1, mitochondrial	DEG_APCC_KENBOX_2	600:604	RKENG	APC,CDC20,FZR1	0.6929	More...
Q96JQ2	Calmin	DEG_APCC_KENBOX_2	411:415	RKENG	APC,CDC20,FZR1	0.9146	More...
Q5T3I0	G patch domain-containing protein 4	DEG_APCC_KENBOX_2	32:36	RKENG	APC,CDC20,FZR1	0.8966	More...
A8MTL3	RING finger protein 212B	DEG_APCC_KENBOX_2	121:125	RKENG	APC,CDC20,FZR1	0.5043	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons