DegronMD - Q13625(TP53BP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G883E	TCGA-A5-A0G1	UCEC	TCGA	PPPY	ITCH	871:874	Mutation rewiring degron network	0.0833
p.G883E	DO42472	UCEC	ICGC	PPPY	ITCH	871:874	Mutation rewiring degron network	0.0833
p.D571E	TCGA-AX-A3FV	UCEC	TCGA	PPAAAVRPF	DEG_SIAH_1	577:585	Mutation rewiring degron network	0.1667
p.D571E	DO219767	UCEC	ICGC	PPAAAVRPF	DEG_SIAH_1	577:585	Mutation rewiring degron network	0.1667
p.E870D	TCGA-B1-A656	KIRP	TCGA	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1667
p.E870D	TCGA-B1-A656	KIRP	TCGA	PPPY	ITCH	871:874	Mutation rewiring degron network	0.3056
p.E870D	DO49741	KIRP	ICGC	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1667
p.E870D	DO49741	KIRP	ICGC	PPPY	ITCH	871:874	Mutation rewiring degron network	0.3056
p.R109I	TCGA-B5-A0JY	UCEC	TCGA	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.1944
p.R109I	DO43041	UCEC	ICGC	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.1944
p.S567L	TCGA-B5-A1MR	UCEC	TCGA	PPAAAVRPF	DEG_SIAH_1	577:585	Mutation rewiring degron network	0.0556
p.S567L	DO41758	UCEC	ICGC	PPAAAVRPF	DEG_SIAH_1	577:585	Mutation rewiring degron network	0.0556
p.P873L	TCGA-BP-4164	KIRC	TCGA	PPPY	ITCH	871:874	Mutation altering degron motif	0.6471
p.P873L	DO19258	KIRC	ICGC	PPPY	ITCH	871:874	Mutation altering degron motif	0.6471
p.E855K	TCGA-DK-A3IT	BLCA	TCGA	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.2222
p.E855K	DO779	BLCA	ICGC	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.2222
p.P881S	TCGA-EE-A2GP	SKCM	TCGA	PPPY	ITCH	871:874	Mutation rewiring degron network	0.1389
p.P881S	DO37422	SKCM	ICGC	PPPY	ITCH	871:874	Mutation rewiring degron network	0.1389
p.P128H	TCGA-EO-A22U	UCEC	TCGA	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.0556
p.P128H	DO43755	UCEC	ICGC	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.0556
p.A324V	TCGA-FS-A4F0	SKCM	TCGA	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation altering degron motif	0.6936
p.A324V	DO37891	SKCM	ICGC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation altering degron motif	0.6936
p.E122D	TCGA-GN-A262	SKCM	TCGA	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.2222
p.E122D	DO37515	SKCM	ICGC	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.2222
p.P879T	TCGA-LN-A49K	ESCA	TCGA	PPPY	ITCH	871:874	Mutation rewiring degron network	0.1944
p.P593S	TCGA-OL-A66I	BRCA	TCGA	PFTPQPS	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.25
p.P593S	TCGA-OL-A66I	BRCA	TCGA	PPAAAVRPF	DEG_SIAH_1	577:585	Mutation rewiring degron network	0.1111
p.P593S	DO44258	BRCA	ICGC	PFTPQPS	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.25
p.P593S	DO44258	BRCA	ICGC	PPAAAVRPF	DEG_SIAH_1	577:585	Mutation rewiring degron network	0.1111
p.D330H	DO48534	BLCA	ICGC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation rewiring degron network	0.1944
p.D313Y	DO219031	BLCA	ICGC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation rewiring degron network	0.1111
p.D598Y	DO225046	BRCA	ICGC	PFTPQPS	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.1111
p.I326M	DO1722	BRCA	ICGC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation rewiring degron network	0.3056
p.M317I	DO44377	CESC	ICGC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation rewiring degron network	0.2222
p.S106G	DO229005	COCA	ICGC	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.1111
p.R589W	DO48224	ESCA	ICGC	PFTPQPS	DEG_SCF_FBW7_1	584:590	Mutation altering degron motif	0.8634
p.G577V	DO231997	ORCA	ICGC	PPAAAVRPF	DEG_SIAH_1	577:585	Mutation altering degron motif	0.7532
p.S596F	DO49484	PACA	ICGC	PFTPQPS	DEG_SCF_FBW7_1	584:590	Mutation rewiring degron network	0.1667
p.G577S	DO232761	PBCA	ICGC	PPAAAVRPF	DEG_SIAH_1	577:585	Mutation altering degron motif	0.6993
p.E331K	DO36256	PRAD	ICGC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation rewiring degron network	0.1667
p.P859A	DO46873	RECA	ICGC	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.7503
p.T324P	DO49073	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation altering degron motif	0.7031
p.E335K	DO41488	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation rewiring degron network	0.0556
p.G124R	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.1667
p.G124R	ACH-000924	Lung Cancer	CCLE	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.1667
p.G124R	NCI-H2172	lung	COSMIC	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.1667
p.H863R	SIDM00247	Gastric Carcinoma	GDSC	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.8244
p.H863R	SIDM01695	Acute Myeloid Leukemia	GDSC	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.8244
p.H863R	SIDM00497	Colorectal Carcinoma	GDSC	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.8244
p.H863R	ACH-000166	Leukemia	CCLE	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.8244
p.H863R	ACH-000356	Gastric Cancer	CCLE	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.8244
p.H863R	ACH-000683	Colon/Colorectal Cancer	CCLE	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.8244
p.H863R	ACH-000773	Lymphoma	CCLE	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.8244
p.H863R	MKN45	stomach	COSMIC	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.8244
p.P105Q	SIDM00176	Chondrosarcoma	GDSC	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.0833
p.P105Q	ACH-002094	Bone Cancer	CCLE	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.0833
p.P105Q	CHSA8926	bone	COSMIC	RKENG	DEG_APCC_KENBOX_2	114:118	Mutation rewiring degron network	0.0833
p.K321N	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation altering degron motif	0.6918
p.K321N	ACH-000637	Esophageal Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation altering degron motif	0.6918
p.K321N	KYSE-520	oesophagus	COSMIC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation altering degron motif	0.6918
p.N849I	SIDM01613	Colorectal Carcinoma	GDSC	LDVYLE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.0556
p.F334L	PF-382	haematopoietic and lymphoid tissue	COSMIC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation rewiring degron network	0.0833
p.R332C	HuH-7	liver	COSMIC	QKENL	DEG_APCC_KENBOX_2	321:325	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TP53BP2

UniProt ID: Q13625

Entrez ID: 7159

Protein name: Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TP53BP2 in