DegronMD

Uniprot ID: Q13625

Source protein: Apoptosis-stimulating of p53 protein 2

Source gene: TP53BP2

Class: LIG_APCC_ABBA_1

Location: 859:864

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9607

ASA_SCORE: 94.2833

COIL: 0.7257

CONS_SCORE: 0.3855

DSS_SCORE: 0.669

HELIX: 0.255

FCONS_SCORE: 1.0032

RIG_SCORE: 0.7392

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E870D	TCGA-B1-A656	KIRP	TCGA	LDVYLE	LIG_APCC_ABBA_1	0.1667
p.E870D	DO49741	KIRP	ICGC	LDVYLE	LIG_APCC_ABBA_1	0.1667
p.E855K	TCGA-DK-A3IT	BLCA	TCGA	LDVYLE	LIG_APCC_ABBA_1	0.2222
p.E855K	DO779	BLCA	ICGC	LDVYLE	LIG_APCC_ABBA_1	0.2222
p.P859A	DO46873	RECA	ICGC	LDVYLE	LIG_APCC_ABBA_1	0.7503
p.H863R	SIDM00247	Gastric Carcinoma	GDSC	LDVYLE	LIG_APCC_ABBA_1	0.8244
p.H863R	SIDM01695	Acute Myeloid Leukemia	GDSC	LDVYLE	LIG_APCC_ABBA_1	0.8244
p.H863R	SIDM00497	Colorectal Carcinoma	GDSC	LDVYLE	LIG_APCC_ABBA_1	0.8244
p.H863R	ACH-000166	Leukemia	CCLE	LDVYLE	LIG_APCC_ABBA_1	0.8244
p.H863R	ACH-000356	Gastric Cancer	CCLE	LDVYLE	LIG_APCC_ABBA_1	0.8244
p.H863R	ACH-000683	Colon/Colorectal Cancer	CCLE	LDVYLE	LIG_APCC_ABBA_1	0.8244
p.H863R	ACH-000773	Lymphoma	CCLE	LDVYLE	LIG_APCC_ABBA_1	0.8244
p.H863R	MKN45	stomach	COSMIC	LDVYLE	LIG_APCC_ABBA_1	0.8244
p.N849I	SIDM01613	Colorectal Carcinoma	GDSC	LDVYLE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13625	Apoptosis-stimulating of p53 protein 2	LIG_APCC_ABBA_1	859:864	LDVYLE	APC,CDC20,FZR1	0.9607	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons