DegronMD

Uniprot ID: Q13625

Source protein: Apoptosis-stimulating of p53 protein 2

Source gene: TP53BP2

Class: DEG_SCF_FBW7_1

Location: 584:590

E3 ligase: FBXW7

DEGRON score: 0.9967

ASA_SCORE: 91.7857

COIL: 0.9629

CONS_SCORE: 0.4784

DSS_SCORE: 0.6763

HELIX: 0.017

FCONS_SCORE: 1.0629

RIG_SCORE: 0.6463

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P593S	TCGA-OL-A66I	BRCA	TCGA	PFTPQPS	DEG_SCF_FBW7_1	0.25
p.P593S	DO44258	BRCA	ICGC	PFTPQPS	DEG_SCF_FBW7_1	0.25
p.D598Y	DO225046	BRCA	ICGC	PFTPQPS	DEG_SCF_FBW7_1	0.1111
p.R589W	DO48224	ESCA	ICGC	PFTPQPS	DEG_SCF_FBW7_1	0.8634
p.S596F	DO49484	PACA	ICGC	PFTPQPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_SCF_FBW7_1	584:590	PFTPQPS	FBXW7	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons