DegronMD

Uniprot ID: Q13625

Source protein: Apoptosis-stimulating of p53 protein 2

Source gene: TP53BP2

Class: DEG_APCC_KENBOX_2

Location: 114:118

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7661

ASA_SCORE: 101.36

COIL: 0.7034

CONS_SCORE: 0.3695

DSS_SCORE: 0.6214

HELIX: 0.2188

FCONS_SCORE: 0.8443

RIG_SCORE: 0.6563

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R109I	TCGA-B5-A0JY	UCEC	TCGA	RKENG	DEG_APCC_KENBOX_2	0.1944
p.R109I	DO43041	UCEC	ICGC	RKENG	DEG_APCC_KENBOX_2	0.1944
p.P128H	TCGA-EO-A22U	UCEC	TCGA	RKENG	DEG_APCC_KENBOX_2	0.0556
p.P128H	DO43755	UCEC	ICGC	RKENG	DEG_APCC_KENBOX_2	0.0556
p.E122D	TCGA-GN-A262	SKCM	TCGA	RKENG	DEG_APCC_KENBOX_2	0.2222
p.E122D	DO37515	SKCM	ICGC	RKENG	DEG_APCC_KENBOX_2	0.2222
p.S106G	DO229005	COCA	ICGC	RKENG	DEG_APCC_KENBOX_2	0.1111
p.G124R	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RKENG	DEG_APCC_KENBOX_2	0.1667
p.G124R	ACH-000924	Lung Cancer	CCLE	RKENG	DEG_APCC_KENBOX_2	0.1667
p.G124R	NCI-H2172	lung	COSMIC	RKENG	DEG_APCC_KENBOX_2	0.1667
p.P105Q	SIDM00176	Chondrosarcoma	GDSC	RKENG	DEG_APCC_KENBOX_2	0.0833
p.P105Q	ACH-002094	Bone Cancer	CCLE	RKENG	DEG_APCC_KENBOX_2	0.0833
p.P105Q	CHSA8926	bone	COSMIC	RKENG	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	114:118	RKENG	APC,CDC20,FZR1	0.7661	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_APCC_KENBOX_2	1588:1592	RKENG	APC,CDC20,FZR1	0.732	More...
Q8TCS8	Polyribonucleotide nucleotidyltransferase 1, mitochondrial	DEG_APCC_KENBOX_2	600:604	RKENG	APC,CDC20,FZR1	0.6929	More...
Q96JQ2	Calmin	DEG_APCC_KENBOX_2	411:415	RKENG	APC,CDC20,FZR1	0.9146	More...
Q5T3I0	G patch domain-containing protein 4	DEG_APCC_KENBOX_2	32:36	RKENG	APC,CDC20,FZR1	0.8966	More...
A8MTL3	RING finger protein 212B	DEG_APCC_KENBOX_2	121:125	RKENG	APC,CDC20,FZR1	0.5043	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons