DegronMD

Uniprot ID: Q96JQ2

Source protein: Calmin

Source gene: CLMN

Class: DEG_APCC_KENBOX_2

Location: 411:415

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9146

ASA_SCORE: 102.94

COIL: 0.856

CONS_SCORE: 0.4233

DSS_SCORE: 0.587

HELIX: 0.1176

FCONS_SCORE: 0.7962

RIG_SCORE: 0.5939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R411K	TCGA-AZ-4315	COAD	TCGA	RKENG	DEG_APCC_KENBOX_2	0.6126
p.R411K	DO8842	COAD	ICGC	RKENG	DEG_APCC_KENBOX_2	0.6126
p.R411T	TCGA-DS-A0VL	CESC	TCGA	RKENG	DEG_APCC_KENBOX_2	0.6765
p.R411T	DO6332	CESC	ICGC	RKENG	DEG_APCC_KENBOX_2	0.6765
p.S409L	TCGA-FR-A729	SKCM	TCGA	RKENG	DEG_APCC_KENBOX_2	0.2778
p.S409L	DO48618	SKCM	ICGC	RKENG	DEG_APCC_KENBOX_2	0.2778
p.S419F	TCGA-H7-8501	HNSC	TCGA	RKENG	DEG_APCC_KENBOX_2	0.6667
p.S419F	DO14202	HNSC	ICGC	RKENG	DEG_APCC_KENBOX_2	0.6667
p.P401S	TCGA-W3-AA1W	SKCM	TCGA	RKENG	DEG_APCC_KENBOX_2	0.0556
p.P401S	DO51277	SKCM	ICGC	RKENG	DEG_APCC_KENBOX_2	0.0556
p.P421L	DO233290	GACA	ICGC	RKENG	DEG_APCC_KENBOX_2	0.1667
p.P401T	SIDM00673	Breast Carcinoma	GDSC	RKENG	DEG_APCC_KENBOX_2	0.0556
p.P401T	HCC70	breast	COSMIC	RKENG	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	114:118	RKENG	APC,CDC20,FZR1	0.7661	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_APCC_KENBOX_2	1588:1592	RKENG	APC,CDC20,FZR1	0.732	More...
Q8TCS8	Polyribonucleotide nucleotidyltransferase 1, mitochondrial	DEG_APCC_KENBOX_2	600:604	RKENG	APC,CDC20,FZR1	0.6929	More...
Q96JQ2	Calmin	DEG_APCC_KENBOX_2	411:415	RKENG	APC,CDC20,FZR1	0.9146	More...
Q5T3I0	G patch domain-containing protein 4	DEG_APCC_KENBOX_2	32:36	RKENG	APC,CDC20,FZR1	0.8966	More...
A8MTL3	RING finger protein 212B	DEG_APCC_KENBOX_2	121:125	RKENG	APC,CDC20,FZR1	0.5043	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons