DegronMD

Uniprot ID: Q8TCS8

Source protein: Polyribonucleotide nucleotidyltransferase 1, mitochondrial

Source gene: PNPT1

Class: DEG_APCC_KENBOX_2

Location: 600:604

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6929

ASA_SCORE: 79.82

COIL: 0.874

CONS_SCORE: 0.4271

DSS_SCORE: 0.4994

HELIX: 0.0748

FCONS_SCORE: 0.9318

RIG_SCORE: 0.646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N603H	TCGA-AG-A002	READ	TCGA	RKENG	DEG_APCC_KENBOX_2	0.7423
p.G604R	TCGA-B5-A1MX	UCEC	TCGA	RKENG	DEG_APCC_KENBOX_2	0.6457
p.G604R	DO41999	UCEC	ICGC	RKENG	DEG_APCC_KENBOX_2	0.6457
p.N590D	DO228483	BRCA	ICGC	RKENG	DEG_APCC_KENBOX_2	0.0556
p.N590D	DO229010	COCA	ICGC	RKENG	DEG_APCC_KENBOX_2	0.0556
p.N590D	DO228941	LICA	ICGC	RKENG	DEG_APCC_KENBOX_2	0.0556
p.S594A	DO229353	LAML	ICGC	RKENG	DEG_APCC_KENBOX_2	0.1667
p.S594A	SIDM01577	Plasma Cell Myeloma	GDSC	RKENG	DEG_APCC_KENBOX_2	0.1667
p.P613S	SIDM00841	Colorectal Carcinoma	GDSC	RKENG	DEG_APCC_KENBOX_2	0.0833
p.P613S	ACH-000651	Colon/Colorectal Cancer	CCLE	RKENG	DEG_APCC_KENBOX_2	0.0833
p.P613S	SW620	large_intestine	COSMIC	RKENG	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	114:118	RKENG	APC,CDC20,FZR1	0.7661	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_APCC_KENBOX_2	1588:1592	RKENG	APC,CDC20,FZR1	0.732	More...
Q8TCS8	Polyribonucleotide nucleotidyltransferase 1, mitochondrial	DEG_APCC_KENBOX_2	600:604	RKENG	APC,CDC20,FZR1	0.6929	More...
Q96JQ2	Calmin	DEG_APCC_KENBOX_2	411:415	RKENG	APC,CDC20,FZR1	0.9146	More...
Q5T3I0	G patch domain-containing protein 4	DEG_APCC_KENBOX_2	32:36	RKENG	APC,CDC20,FZR1	0.8966	More...
A8MTL3	RING finger protein 212B	DEG_APCC_KENBOX_2	121:125	RKENG	APC,CDC20,FZR1	0.5043	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons