DegronMD - Q8TCS8(PNPT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A108S	TCGA-69-7765	LUAD	TCGA	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1944
p.A108S	DO23580	LUAD	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1944
p.N603H	TCGA-AG-A002	READ	TCGA	RKENG	DEG_APCC_KENBOX_2	600:604	Mutation altering degron motif	0.7423
p.P97L	TCGA-AX-A06F	UCEC	TCGA	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.2222
p.P97L	DO41752	UCEC	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.2222
p.G604R	TCGA-B5-A1MX	UCEC	TCGA	RKENG	DEG_APCC_KENBOX_2	600:604	Mutation altering degron motif	0.6457
p.G604R	DO41999	UCEC	ICGC	RKENG	DEG_APCC_KENBOX_2	600:604	Mutation altering degron motif	0.6457
p.S93F	TCGA-BF-A1PX	SKCM	TCGA	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1111
p.S93F	DO51236	SKCM	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1111
p.P92H	TCGA-D3-A2JC	SKCM	TCGA	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.0833
p.P92H	DO47578	SKCM	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.0833
p.P113S	TCGA-EB-A41A	SKCM	TCGA	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.0556
p.P113S	DO220877	MELA	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.0556
p.P113S	DO37429	SKCM	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.0556
p.P113S	ACH-001844	Bile Duct Cancer	CCLE	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.0556
p.N590D	DO228483	BRCA	ICGC	RKENG	DEG_APCC_KENBOX_2	600:604	Mutation rewiring degron network	0.0556
p.N590D	DO229010	COCA	ICGC	RKENG	DEG_APCC_KENBOX_2	600:604	Mutation rewiring degron network	0.0556
p.N590D	DO228941	LICA	ICGC	RKENG	DEG_APCC_KENBOX_2	600:604	Mutation rewiring degron network	0.0556
p.S594A	DO229353	LAML	ICGC	RKENG	DEG_APCC_KENBOX_2	600:604	Mutation rewiring degron network	0.1667
p.S594A	SIDM01577	Plasma Cell Myeloma	GDSC	RKENG	DEG_APCC_KENBOX_2	600:604	Mutation rewiring degron network	0.1667
p.P97H	DO228900	LICA	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.2222
p.A108E	DO229029	LICA	ICGC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.1944
p.K105N	SIDM02039	Colorectal Carcinoma	GDSC	DYR	CBL_MET	101:103	Mutation rewiring degron network	0.2778
p.P613S	SIDM00841	Colorectal Carcinoma	GDSC	RKENG	DEG_APCC_KENBOX_2	600:604	Mutation rewiring degron network	0.0833
p.P613S	ACH-000651	Colon/Colorectal Cancer	CCLE	RKENG	DEG_APCC_KENBOX_2	600:604	Mutation rewiring degron network	0.0833
p.P613S	SW620	large intestine	COSMIC	RKENG	DEG_APCC_KENBOX_2	600:604	Mutation rewiring degron network	0.0833

Kaplan plot for PNPT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PNPT1

UniProt ID: Q8TCS8

Entrez ID: 87178

Protein name: Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PNPT1 in