DegronMD - Q96JQ2(CLMN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G803V	TCGA-55-7725	LUAD	TCGA	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation rewiring degron network	0.2778
p.G803V	DO24636	LUAD	ICGC	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation rewiring degron network	0.2778
p.K472R	TCGA-77-7141	LUSC	TCGA	PESSS	DEG_SPOP_SBC_1	482:486	Mutation substituting flanking lysine	0.1667
p.K472R	DO26450	LUSC	ICGC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation substituting flanking lysine	0.1667
p.D831Y	TCGA-AA-3510	COAD	TCGA	TKEND	DEG_APCC_KENBOX_2	827:831	Mutation altering degron motif	0.6214
p.D831Y	DO7783	COAD	ICGC	TKEND	DEG_APCC_KENBOX_2	827:831	Mutation altering degron motif	0.6214
p.D831Y	SIDM00534	Colorectal Carcinoma	GDSC	TKEND	DEG_APCC_KENBOX_2	827:831	Mutation altering degron motif	0.6214
p.D831Y	ACH-000986	Colon/Colorectal Cancer	CCLE	TKEND	DEG_APCC_KENBOX_2	827:831	Mutation altering degron motif	0.6214
p.D831Y	HT-115	large intestine	COSMIC	TKEND	DEG_APCC_KENBOX_2	827:831	Mutation altering degron motif	0.6214
p.A814T	TCGA-AJ-A3BG	UCEC	TCGA	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation rewiring degron network	0.2778
p.A814T	DO42633	UCEC	ICGC	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation rewiring degron network	0.2778
p.R411K	TCGA-AZ-4315	COAD	TCGA	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation altering degron motif	0.6126
p.R411K	DO8842	COAD	ICGC	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation altering degron motif	0.6126
p.A490T	TCGA-B5-A3FC	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.2222
p.A490T	DO41871	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.2222
p.A490T	SIDM00150	Colorectal Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.2222
p.A490T	ACH-000969	Colon/Colorectal Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.2222
p.A490T	KM12	large intestine	COSMIC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.2222
p.S486F	TCGA-BA-5558	HNSC	TCGA	PESSS	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.7982
p.S486F	DO15783	HNSC	ICGC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.7982
p.A180T	TCGA-BR-7707	STAD	TCGA	PPTPTAE	DEG_SCF_FBW7_2	170:176	Mutation rewiring degron network	0.2222
p.A180T	DO38487	STAD	ICGC	PPTPTAE	DEG_SCF_FBW7_2	170:176	Mutation rewiring degron network	0.2222
p.M833I	TCGA-D7-6528	STAD	TCGA	TKEND	DEG_APCC_KENBOX_2	827:831	Mutation rewiring degron network	0.2778
p.M833I	DO38547	STAD	ICGC	TKEND	DEG_APCC_KENBOX_2	827:831	Mutation rewiring degron network	0.2778
p.R411T	TCGA-DS-A0VL	CESC	TCGA	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation altering degron motif	0.6765
p.R411T	DO6332	CESC	ICGC	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation altering degron motif	0.6765
p.E483K	TCGA-EE-A2M5	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.591
p.E483K	DO222423	MELA	ICGC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.591
p.E483K	DO37425	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.591
p.G162D	TCGA-F7-A624	HNSC	TCGA	PPTPTAE	DEG_SCF_FBW7_2	170:176	Mutation rewiring degron network	0.1111
p.G162D	DO233885	GACA	ICGC	PPTPTAE	DEG_SCF_FBW7_2	170:176	Mutation rewiring degron network	0.1111
p.G162D	DO44440	HNSC	ICGC	PPTPTAE	DEG_SCF_FBW7_2	170:176	Mutation rewiring degron network	0.1111
p.S484F	TCGA-FD-A62P	BLCA	TCGA	PESSS	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.7982
p.S484F	DO44054	BLCA	ICGC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation altering degron motif	0.7982
p.S409L	TCGA-FR-A729	SKCM	TCGA	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation rewiring degron network	0.2778
p.S409L	DO48618	SKCM	ICGC	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation rewiring degron network	0.2778
p.S419F	TCGA-H7-8501	HNSC	TCGA	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation blocking phosphorylation signal	0.6667
p.S419F	DO14202	HNSC	ICGC	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation blocking phosphorylation signal	0.6667
p.P401S	TCGA-W3-AA1W	SKCM	TCGA	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation rewiring degron network	0.0556
p.P401S	DO51277	SKCM	ICGC	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation rewiring degron network	0.0556
p.L816P	DO227701	BRCA	ICGC	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation rewiring degron network	0.2222
p.Q474P	DO222645	ESCA	ICGC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1111
p.P421L	DO233290	GACA	ICGC	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation rewiring degron network	0.1667
p.S168Y	DO229018	LICA	ICGC	PPTPTAE	DEG_SCF_FBW7_2	170:176	Mutation rewiring degron network	0.2778
p.G804S	DO23543	LIRI	ICGC	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation rewiring degron network	0.3056
p.S479L	DO222868	MELA	ICGC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.S479L	SIDM01182	Bladder Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.S479L	ACH-000522	Bladder Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.S479L	UM-UC-3	urinary tract	COSMIC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.V489F	SIDM00422	Hodgkin's Lymphoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.V489F	SIDM00454	Rhabdomyosarcoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.V489F	SIDM00690	Head and Neck Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.V489F	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.V489F	SIDM00971	Breast Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.V489F	SIDM00844	Burkitt's Lymphoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.V489F	SIDM00807	Bladder Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.V489F	SIDM00930	Osteosarcoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.V489F	SIDM00808	Burkitt's Lymphoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.V489F	SIDM00785	Acute Myeloid Leukemia	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.V489F	SIDM01254	Burkitt's Lymphoma	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.25
p.G161R	SIDM00120	Prostate Carcinoma	GDSC	PPTPTAE	DEG_SCF_FBW7_2	170:176	Mutation rewiring degron network	0.0833
p.G161R	ACH-000979	Prostate Cancer	CCLE	PPTPTAE	DEG_SCF_FBW7_2	170:176	Mutation rewiring degron network	0.0833
p.G161R	DU-145	prostate	COSMIC	PPTPTAE	DEG_SCF_FBW7_2	170:176	Mutation rewiring degron network	0.0833
p.F494L	SIDM00007	Other Solid Cancers	GDSC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1111
p.F494L	ACH-001550	Skin Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1111
p.F494L	MCC13	skin	COSMIC	PESSS	DEG_SPOP_SBC_1	482:486	Mutation rewiring degron network	0.1111
p.G806A	SIDM00676	Bladder Carcinoma	GDSC	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation altering degron motif	0.6429
p.G806A	ACH-000547	Bladder Cancer	CCLE	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation altering degron motif	0.6429
p.G806A	HT-1197	urinary tract	COSMIC	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation altering degron motif	0.6429
p.Y799H	SIDM00537	Colorectal Carcinoma	GDSC	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation rewiring degron network	0.1667
p.Y799H	ACH-000982	Colon/Colorectal Cancer	CCLE	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation rewiring degron network	0.1667
p.Y799H	ACH-001345	Colon/Colorectal Cancer	CCLE	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation rewiring degron network	0.1667
p.Y799H	GP5d	large intestine	COSMIC	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation rewiring degron network	0.1667
p.P401T	SIDM00673	Breast Carcinoma	GDSC	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation rewiring degron network	0.0556
p.P401T	HCC70	breast	COSMIC	RKENG	DEG_APCC_KENBOX_2	411:415	Mutation rewiring degron network	0.0556
p.R802G	ACH-000996	Endometrial/Uterine Cancer	CCLE	VGTTPASE	DEG_SCF_FBW7_2	805:812	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLMN

UniProt ID: Q96JQ2

Entrez ID: 79789

Protein name: Calmin (Calponin-like transmembrane domain protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLMN in