DegronMD

Uniprot ID: Q96JQ2

Source protein: Calmin

Source gene: CLMN

Class: DEG_APCC_KENBOX_2

Location: 827:831

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9995

ASA_SCORE: 104.56

COIL: 0.8422

CONS_SCORE: 0.4612

DSS_SCORE: 0.9398

HELIX: 0.141

FCONS_SCORE: 1.3094

RIG_SCORE: 0.5634

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D831Y	TCGA-AA-3510	COAD	TCGA	TKEND	DEG_APCC_KENBOX_2	0.6214
p.D831Y	DO7783	COAD	ICGC	TKEND	DEG_APCC_KENBOX_2	0.6214
p.D831Y	SIDM00534	Colorectal Carcinoma	GDSC	TKEND	DEG_APCC_KENBOX_2	0.6214
p.D831Y	ACH-000986	Colon/Colorectal Cancer	CCLE	TKEND	DEG_APCC_KENBOX_2	0.6214
p.D831Y	HT-115	large_intestine	COSMIC	TKEND	DEG_APCC_KENBOX_2	0.6214
p.M833I	TCGA-D7-6528	STAD	TCGA	TKEND	DEG_APCC_KENBOX_2	0.2778
p.M833I	DO38547	STAD	ICGC	TKEND	DEG_APCC_KENBOX_2	0.2778

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JQ2	Calmin	DEG_APCC_KENBOX_2	827:831	TKEND	APC,CDC20,FZR1	0.9995	More...
Q9NTI5	Sister chromatid cohesion protein PDS5 homolog B	DEG_APCC_KENBOX_2	1401:1405	TKEND	APC,CDC20,FZR1	0.9943	More...

Showing 1 to 2 of 2 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons