DegronMD

Uniprot ID: Q9NTI5

Source protein: Sister chromatid cohesion protein PDS5 homolog B

Source gene: PDS5B

Class: DEG_APCC_KENBOX_2

Location: 1401:1405

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9943

ASA_SCORE: 117.76

COIL: 0.8266

CONS_SCORE: 0.2638

DSS_SCORE: 0.7148

HELIX: 0.155

FCONS_SCORE: 1.012

RIG_SCORE: 0.6145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1392L	TCGA-17-Z028	LUAD	TCGA	TKEND	DEG_APCC_KENBOX_2	0.0833
p.R1392L	DO229038	LICA	ICGC	TKEND	DEG_APCC_KENBOX_2	0.0833
p.N1404S	TCGA-BG-A220	UCEC	TCGA	TKEND	DEG_APCC_KENBOX_2	0.7069
p.N1404S	DO41784	UCEC	ICGC	TKEND	DEG_APCC_KENBOX_2	0.7069
p.V1393I	TCGA-BR-4292	STAD	TCGA	TKEND	DEG_APCC_KENBOX_2	0.1111
p.V1393I	DO38495	STAD	ICGC	TKEND	DEG_APCC_KENBOX_2	0.1111
p.G1415D	TCGA-YG-AA3O	SKCM	TCGA	TKEND	DEG_APCC_KENBOX_2	0.0556
p.G1415D	DO51299	SKCM	ICGC	TKEND	DEG_APCC_KENBOX_2	0.0556
p.R1395L	DO228900	LICA	ICGC	TKEND	DEG_APCC_KENBOX_2	0.1667
p.G1415V	DO228948	LICA	ICGC	TKEND	DEG_APCC_KENBOX_2	0.0556
p.G1415V	DO229037	LICA	ICGC	TKEND	DEG_APCC_KENBOX_2	0.0556
p.R1392C	SIDM00189	Melanoma	GDSC	TKEND	DEG_APCC_KENBOX_2	0.0833
p.R1392C	CP67-MEL	skin	COSMIC	TKEND	DEG_APCC_KENBOX_2	0.0833
p.R1395C	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	TKEND	DEG_APCC_KENBOX_2	0.1667
p.R1395C	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	TKEND	DEG_APCC_KENBOX_2	0.1667
p.A1399G	SIDM00561	Other Blood Cancers	GDSC	TKEND	DEG_APCC_KENBOX_2	0.2778
p.A1399G	ACH-001856	Bile Duct Cancer	CCLE	TKEND	DEG_APCC_KENBOX_2	0.2778
p.A1399G	ACH-002274	Leukemia	CCLE	TKEND	DEG_APCC_KENBOX_2	0.2778
p.A1399G	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	TKEND	DEG_APCC_KENBOX_2	0.2778
p.R1395H	ACH-001518	Endometrial/Uterine Cancer	CCLE	TKEND	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NTI5	Sister chromatid cohesion protein PDS5 homolog B	DEG_APCC_KENBOX_2	1401:1405	TKEND	APC,CDC20,FZR1	0.9943	More...
Q96JQ2	Calmin	DEG_APCC_KENBOX_2	827:831	TKEND	APC,CDC20,FZR1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons