DegronMD - Q9NTI5(PDS5B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q1368L	TCGA-05-4418	LUAD	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.0556
p.Q1368L	DO23814	LUAD	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.0556
p.R1392L	TCGA-17-Z028	LUAD	TCGA	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.0833
p.R1392L	TCGA-17-Z028	LUAD	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.1389
p.R1392L	DO229038	LICA	ICGC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.0833
p.R1392L	DO229038	LICA	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.1389
p.T1381M	TCGA-A5-A0GB	UCEC	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation altering degron motif	0.8534
p.T1381M	TCGA-G4-6586	COAD	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation altering degron motif	0.8534
p.T1381M	DO9698	COAD	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation altering degron motif	0.8534
p.T1381M	DO41434	UCEC	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation altering degron motif	0.8534
p.R1151Q	TCGA-AX-A0J0	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1389
p.R1151Q	TCGA-CA-6717	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1389
p.R1151Q	TCGA-DF-A2KU	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1389
p.R1151Q	TCGA-EI-6917	READ	TCGA	ASSSS	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1389
p.R1151Q	TCGA-EY-A1GI	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1389
p.R1151Q	DO8264	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1389
p.R1151Q	DO36881	READ	ICGC	ASSSS	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1389
p.R1151Q	DO223286	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1389
p.R1151Q	DO41211	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1389
p.R1151Q	DO41133	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1389
p.K1389Q	TCGA-B5-A0JY	UCEC	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation substituting flanking lysine	0.3333
p.K1389Q	DO43041	UCEC	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation substituting flanking lysine	0.3333
p.N1404S	TCGA-BG-A220	UCEC	TCGA	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation altering degron motif	0.7069
p.N1404S	DO41784	UCEC	ICGC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation altering degron motif	0.7069
p.V1393I	TCGA-BR-4292	STAD	TCGA	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.1111
p.V1393I	TCGA-BR-4292	STAD	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.1111
p.V1393I	DO38495	STAD	ICGC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.1111
p.V1393I	DO38495	STAD	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.1111
p.G1415D	TCGA-YG-AA3O	SKCM	TCGA	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.0556
p.G1415D	DO51299	SKCM	ICGC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.0556
p.R1395L	DO228900	LICA	ICGC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.1667
p.R1395L	DO228900	LICA	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.0556
p.G1415V	DO228948	LICA	ICGC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.0556
p.G1415V	DO229037	LICA	ICGC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.0556
p.R1169I	DO229026	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1389
p.P1387Q	DO229050	LICA	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.2778
p.Q1386K	DO229232	THCA	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.3056
p.R1392C	SIDM00189	Melanoma	GDSC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.0833
p.R1392C	SIDM00189	Melanoma	GDSC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.1389
p.R1392C	CP67-MEL	skin	COSMIC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.0833
p.R1392C	CP67-MEL	skin	COSMIC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.1389
p.R1395C	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.1667
p.R1395C	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.0556
p.R1395C	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.1667
p.R1395C	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.0556
p.P1371L	SIDM00333	Endometrial Carcinoma	GDSC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.1389
p.P1371L	ACH-000988	Endometrial/Uterine Cancer	CCLE	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.1389
p.P1371L	MFE-319	endometrium	COSMIC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.1389
p.A1399G	SIDM00561	Other Blood Cancers	GDSC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.2778
p.A1399G	ACH-001856	Bile Duct Cancer	CCLE	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.2778
p.A1399G	ACH-002274	Leukemia	CCLE	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.2778
p.A1399G	MLMA	haematopoietic and lymphoid tissue	COSMIC	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.2778
p.K1388N	SIDM01611	Endometrial Carcinoma	GDSC	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation substituting flanking lysine	0.3611
p.K1388N	ACH-000996	Endometrial/Uterine Cancer	CCLE	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation substituting flanking lysine	0.3611
p.R1395H	ACH-001518	Endometrial/Uterine Cancer	CCLE	TKEND	DEG_APCC_KENBOX_2	1401:1405	Mutation rewiring degron network	0.1667
p.R1395H	ACH-001518	Endometrial/Uterine Cancer	CCLE	PSKTPSPS	DEG_SCF_FBW7_1	1378:1385	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDS5B

UniProt ID: Q9NTI5

Entrez ID: 23047

Protein name: Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDS5B in