DegronMD

Uniprot ID: Q9NTI5

Source protein: Sister chromatid cohesion protein PDS5 homolog B

Source gene: PDS5B

Class: DEG_SCF_FBW7_1

Location: 1378:1385

E3 ligase: FBXW7

DEGRON score: 0.9505

ASA_SCORE: 107.025

COIL: 0.9718

CONS_SCORE: 0.2577

DSS_SCORE: 0.885

HELIX: 0.0125

FCONS_SCORE: 0.9436

RIG_SCORE: 0.4883

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1368L	TCGA-05-4418	LUAD	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	0.0556
p.Q1368L	DO23814	LUAD	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	0.0556
p.R1392L	TCGA-17-Z028	LUAD	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	0.1389
p.R1392L	DO229038	LICA	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	0.1389
p.T1381M	TCGA-A5-A0GB	UCEC	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	0.8534
p.T1381M	TCGA-G4-6586	COAD	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	0.8534
p.T1381M	DO9698	COAD	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	0.8534
p.T1381M	DO41434	UCEC	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	0.8534
p.K1389Q	TCGA-B5-A0JY	UCEC	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	0.3333
p.K1389Q	DO43041	UCEC	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	0.3333
p.V1393I	TCGA-BR-4292	STAD	TCGA	PSKTPSPS	DEG_SCF_FBW7_1	0.1111
p.V1393I	DO38495	STAD	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	0.1111
p.R1395L	DO228900	LICA	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	0.0556
p.P1387Q	DO229050	LICA	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	0.2778
p.Q1386K	DO229232	THCA	ICGC	PSKTPSPS	DEG_SCF_FBW7_1	0.3056
p.R1392C	SIDM00189	Melanoma	GDSC	PSKTPSPS	DEG_SCF_FBW7_1	0.1389
p.R1392C	CP67-MEL	skin	COSMIC	PSKTPSPS	DEG_SCF_FBW7_1	0.1389
p.R1395C	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSKTPSPS	DEG_SCF_FBW7_1	0.0556
p.R1395C	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	PSKTPSPS	DEG_SCF_FBW7_1	0.0556
p.P1371L	SIDM00333	Endometrial Carcinoma	GDSC	PSKTPSPS	DEG_SCF_FBW7_1	0.1389
p.P1371L	ACH-000988	Endometrial/Uterine Cancer	CCLE	PSKTPSPS	DEG_SCF_FBW7_1	0.1389
p.P1371L	MFE-319	endometrium	COSMIC	PSKTPSPS	DEG_SCF_FBW7_1	0.1389
p.K1388N	SIDM01611	Endometrial Carcinoma	GDSC	PSKTPSPS	DEG_SCF_FBW7_1	0.3611
p.K1388N	ACH-000996	Endometrial/Uterine Cancer	CCLE	PSKTPSPS	DEG_SCF_FBW7_1	0.3611
p.R1395H	ACH-001518	Endometrial/Uterine Cancer	CCLE	PSKTPSPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NTI5	Sister chromatid cohesion protein PDS5 homolog B	DEG_SCF_FBW7_1	1378:1385	PSKTPSPS	FBXW7	0.9505	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSKTPSPS

Degron related mutations and impact score

Drug responses associated with PDS5B mutations

All proteins holding degron of PSKTPSPS