DegronMD

Uniprot ID: Q96JQ2

Source protein: Calmin

Source gene: CLMN

Class: DEG_SCF_FBW7_2

Location: 805:812

E3 ligase: FBXW7

DEGRON score: 0.9927

ASA_SCORE: 79.7375

COIL: 0.9124

CONS_SCORE: 0.3505

DSS_SCORE: 0.7297

HELIX: 0.03

FCONS_SCORE: 1.0975

RIG_SCORE: 0.5721

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G803V	TCGA-55-7725	LUAD	TCGA	VGTTPASE	DEG_SCF_FBW7_2	0.2778
p.G803V	DO24636	LUAD	ICGC	VGTTPASE	DEG_SCF_FBW7_2	0.2778
p.A814T	TCGA-AJ-A3BG	UCEC	TCGA	VGTTPASE	DEG_SCF_FBW7_2	0.2778
p.A814T	DO42633	UCEC	ICGC	VGTTPASE	DEG_SCF_FBW7_2	0.2778
p.L816P	DO227701	BRCA	ICGC	VGTTPASE	DEG_SCF_FBW7_2	0.2222
p.G804S	DO23543	LIRI	ICGC	VGTTPASE	DEG_SCF_FBW7_2	0.3056
p.G806A	SIDM00676	Bladder Carcinoma	GDSC	VGTTPASE	DEG_SCF_FBW7_2	0.6429
p.G806A	ACH-000547	Bladder Cancer	CCLE	VGTTPASE	DEG_SCF_FBW7_2	0.6429
p.G806A	HT-1197	urinary_tract	COSMIC	VGTTPASE	DEG_SCF_FBW7_2	0.6429
p.Y799H	SIDM00537	Colorectal Carcinoma	GDSC	VGTTPASE	DEG_SCF_FBW7_2	0.1667
p.Y799H	ACH-000982	Colon/Colorectal Cancer	CCLE	VGTTPASE	DEG_SCF_FBW7_2	0.1667
p.Y799H	ACH-001345	Colon/Colorectal Cancer	CCLE	VGTTPASE	DEG_SCF_FBW7_2	0.1667
p.Y799H	GP5d	large_intestine	COSMIC	VGTTPASE	DEG_SCF_FBW7_2	0.1667
p.R802G	ACH-000996	Endometrial/Uterine Cancer	CCLE	VGTTPASE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JQ2	Calmin	DEG_SCF_FBW7_2	805:812	VGTTPASE	FBXW7	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons