DegronMD

Uniprot ID: Q96JQ2

Source protein: Calmin

Source gene: CLMN

Class: DEG_SCF_FBW7_2

Location: 170:176

E3 ligase: FBXW7

DEGRON score: 0.7133

ASA_SCORE: 90.1429

COIL: 0.8581

CONS_SCORE: 0.4848

DSS_SCORE: 0.5826

HELIX: 0.1254

FCONS_SCORE: 1.0247

RIG_SCORE: 0.6438

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A180T	TCGA-BR-7707	STAD	TCGA	PPTPTAE	DEG_SCF_FBW7_2	0.2222
p.A180T	DO38487	STAD	ICGC	PPTPTAE	DEG_SCF_FBW7_2	0.2222
p.G162D	TCGA-F7-A624	HNSC	TCGA	PPTPTAE	DEG_SCF_FBW7_2	0.1111
p.G162D	DO233885	GACA	ICGC	PPTPTAE	DEG_SCF_FBW7_2	0.1111
p.G162D	DO44440	HNSC	ICGC	PPTPTAE	DEG_SCF_FBW7_2	0.1111
p.S168Y	DO229018	LICA	ICGC	PPTPTAE	DEG_SCF_FBW7_2	0.2778
p.G161R	SIDM00120	Prostate Carcinoma	GDSC	PPTPTAE	DEG_SCF_FBW7_2	0.0833
p.G161R	ACH-000979	Prostate Cancer	CCLE	PPTPTAE	DEG_SCF_FBW7_2	0.0833
p.G161R	DU-145	prostate	COSMIC	PPTPTAE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JQ2	Calmin	DEG_SCF_FBW7_2	170:176	PPTPTAE	FBXW7	0.7133	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons