DegronMD

Uniprot ID: Q13625

Source protein: Apoptosis-stimulating of p53 protein 2

Source gene: TP53BP2

Class: DEG_APCC_KENBOX_2

Location: 321:325

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9617

ASA_SCORE: 118.02

COIL: 0.6276

CONS_SCORE: 0.4845

DSS_SCORE: 0.5294

HELIX: 0.3674

FCONS_SCORE: 1.0649

RIG_SCORE: 0.7243

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A324V	TCGA-FS-A4F0	SKCM	TCGA	QKENL	DEG_APCC_KENBOX_2	0.6936
p.A324V	DO37891	SKCM	ICGC	QKENL	DEG_APCC_KENBOX_2	0.6936
p.D330H	DO48534	BLCA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1944
p.D313Y	DO219031	BLCA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1111
p.I326M	DO1722	BRCA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.3056
p.M317I	DO44377	CESC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.2222
p.E331K	DO36256	PRAD	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1667
p.T324P	DO49073	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.7031
p.E335K	DO41488	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.0556
p.K321N	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.6918
p.K321N	ACH-000637	Esophageal Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	0.6918
p.K321N	KYSE-520	oesophagus	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.6918
p.F334L	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.0833
p.R332C	HuH-7	liver	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15078	Centrosomal protein of 290 kDa	DEG_APCC_KENBOX_2	2062:2066	QKENL	APC,CDC20,FZR1	0.7619	More...
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	321:325	QKENL	APC,CDC20,FZR1	0.9617	More...
Q15643	Thyroid receptor-interacting protein 11	DEG_APCC_KENBOX_2	603:607	QKENL	APC,CDC20,FZR1	0.8324	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_APCC_KENBOX_2	874:878	QKENL	APC,CDC20,FZR1	0.9983	More...
Q3ZCT1	Zinc finger protein 260	DEG_APCC_KENBOX_2	203:207	QKENL	APC,CDC20,FZR1	0.7516	More...
Q9Y5G1	Protocadherin gamma-B3	DEG_APCC_KENBOX_2	182:186	QKENL	APC,CDC20,FZR1	0.9259	More...
Q9H7R5	Zinc finger protein 665	DEG_APCC_KENBOX_2	116:120	QKENL	APC,CDC20,FZR1	0.7555	More...
Q6NSI1	Putative ankyrin repeat domain-containing protein 26-like protein	DEG_APCC_KENBOX_2	204:208	QKENL	APC,CDC20,FZR1	0.9904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons