DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
QKENL
Uniprot ID:
Q6NSI1
Source protein:
Putative ankyrin repeat domain-containing protein 26-like protein
Source gene:
ANKRD26P1
Class:
DEG_APCC_KENBOX_2
Location:
204:208
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9904
ASA_SCORE:
64.56
COIL:
0.8662
CONS_SCORE:
0.5114
DSS_SCORE:
0.4013
HELIX:
0.059
FCONS_SCORE:
1.1144
RIG_SCORE:
0.7709
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ANKRD26P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QKENL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15078
Centrosomal protein of 290 kDa
DEG_APCC_KENBOX_2
2062:2066
QKENL
APC,CDC20,FZR1
0.7619
More...
Q13625
Apoptosis-stimulating of p53 protein 2
DEG_APCC_KENBOX_2
321:325
QKENL
APC,CDC20,FZR1
0.9617
More...
Q15643
Thyroid receptor-interacting protein 11
DEG_APCC_KENBOX_2
603:607
QKENL
APC,CDC20,FZR1
0.8324
More...
Q9H2D6
TRIO and F-actin-binding protein
DEG_APCC_KENBOX_2
874:878
QKENL
APC,CDC20,FZR1
0.9983
More...
Q3ZCT1
Zinc finger protein 260
DEG_APCC_KENBOX_2
203:207
QKENL
APC,CDC20,FZR1
0.7516
More...
Q9Y5G1
Protocadherin gamma-B3
DEG_APCC_KENBOX_2
182:186
QKENL
APC,CDC20,FZR1
0.9259
More...
Q9H7R5
Zinc finger protein 665
DEG_APCC_KENBOX_2
116:120
QKENL
APC,CDC20,FZR1
0.7555
More...
Q6NSI1
Putative ankyrin repeat domain-containing protein 26-like protein
DEG_APCC_KENBOX_2
204:208
QKENL
APC,CDC20,FZR1
0.9904
More...