DegronMD

Uniprot ID: Q3ZCT1

Source protein: Zinc finger protein 260

Source gene: ZNF260

Class: DEG_APCC_KENBOX_2

Location: 203:207

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7516

ASA_SCORE: 80.26

COIL: 0.6996

CONS_SCORE: 0.6319

DSS_SCORE: 0.2588

HELIX: 0.149

FCONS_SCORE: 0.8547

RIG_SCORE: 0.802

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H210Y	DO233782	GACA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.25
p.G198E	SIDM01368	Gastric Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.1944
p.G198E	ACH-000255	Gastric Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	0.1944
p.E196K	DO220906	MELA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1389
p.S195G	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.1111
p.S195G	ACH-000914	Lymphoma	CCLE	QKENL	DEG_APCC_KENBOX_2	0.1111
p.S195G	HT	haematopoietic_and_lymphoid_tissue	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.1111
p.G216R	TCGA-95-7043	LUAD	TCGA	QKENL	DEG_APCC_KENBOX_2	0.0833
p.G216R	DO24739	LUAD	ICGC	QKENL	DEG_APCC_KENBOX_2	0.0833

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	321:325	QKENL	APC,CDC20,FZR1	0.9617	More...
O15078	Centrosomal protein of 290 kDa	DEG_APCC_KENBOX_2	2062:2066	QKENL	APC,CDC20,FZR1	0.7619	More...
Q9Y5G1	Protocadherin gamma-B3	DEG_APCC_KENBOX_2	182:186	QKENL	APC,CDC20,FZR1	0.9259	More...
Q6NSI1	Putative ankyrin repeat domain-containing protein 26-like protein	DEG_APCC_KENBOX_2	204:208	QKENL	APC,CDC20,FZR1	0.9904	More...
Q15643	Thyroid receptor-interacting protein 11	DEG_APCC_KENBOX_2	603:607	QKENL	APC,CDC20,FZR1	0.8324	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_APCC_KENBOX_2	874:878	QKENL	APC,CDC20,FZR1	0.9983	More...
Q3ZCT1	Zinc finger protein 260	DEG_APCC_KENBOX_2	203:207	QKENL	APC,CDC20,FZR1	0.7516	More...
Q9H7R5	Zinc finger protein 665	DEG_APCC_KENBOX_2	116:120	QKENL	APC,CDC20,FZR1	0.7555	More...

Showing 1 to 8 of 8 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons