DegronMD

Uniprot ID: Q9Y5G1

Source protein: Protocadherin gamma-B3

Source gene: PCDHGB3

Class: DEG_APCC_KENBOX_2

Location: 182:186

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9259

ASA_SCORE: 80.5

COIL: 0.4378

CONS_SCORE: 0.6506

DSS_SCORE: 0.4612

HELIX: 0.0018

FCONS_SCORE: 1.0981

RIG_SCORE: 0.7317

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H177Q	TCGA-55-8092	LUAD	TCGA	QKENL	DEG_APCC_KENBOX_2	0.1944
p.H177Q	DO26220	LUAD	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1944
p.D175A	TCGA-F5-6814	READ	TCGA	QKENL	DEG_APCC_KENBOX_2	0.1389
p.D175A	DO36556	READ	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1389
p.S179C	TCGA-G2-A2EO	BLCA	TCGA	QKENL	DEG_APCC_KENBOX_2	0.25
p.S179C	DO456	BLCA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.25
p.S189I	TCGA-HT-7479	LGG	TCGA	QKENL	DEG_APCC_KENBOX_2	0.25
p.S189I	DO22277	LGG	ICGC	QKENL	DEG_APCC_KENBOX_2	0.25
p.Y191C	DO225346	BRCA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1944
p.P176L	DO224786	COCA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1667
p.P176L	DO51465	PACA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1667
p.E193K	DO48286	ESCA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1389
p.L196P	DO233652	GACA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.0556
p.S189R	DO229096	UTCA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.25
p.F178Y	SIDM01149	Small Cell Lung Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.2222
p.F178Y	ACH-001365	Lung Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	0.2222
p.F178Y	NCI-H847	lung	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.2222
p.G188C	ACH-000870	Lung Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15078	Centrosomal protein of 290 kDa	DEG_APCC_KENBOX_2	2062:2066	QKENL	APC,CDC20,FZR1	0.7619	More...
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	321:325	QKENL	APC,CDC20,FZR1	0.9617	More...
Q15643	Thyroid receptor-interacting protein 11	DEG_APCC_KENBOX_2	603:607	QKENL	APC,CDC20,FZR1	0.8324	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_APCC_KENBOX_2	874:878	QKENL	APC,CDC20,FZR1	0.9983	More...
Q3ZCT1	Zinc finger protein 260	DEG_APCC_KENBOX_2	203:207	QKENL	APC,CDC20,FZR1	0.7516	More...
Q9Y5G1	Protocadherin gamma-B3	DEG_APCC_KENBOX_2	182:186	QKENL	APC,CDC20,FZR1	0.9259	More...
Q9H7R5	Zinc finger protein 665	DEG_APCC_KENBOX_2	116:120	QKENL	APC,CDC20,FZR1	0.7555	More...
Q6NSI1	Putative ankyrin repeat domain-containing protein 26-like protein	DEG_APCC_KENBOX_2	204:208	QKENL	APC,CDC20,FZR1	0.9904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons