DegronMD

Uniprot ID: O15078

Source protein: Centrosomal protein of 290 kDa

Source gene: CEP290

Class: DEG_APCC_KENBOX_2

Location: 2062:2066

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7619

ASA_SCORE: 112.34

COIL: 0.0386

CONS_SCORE: 0.7521

DSS_SCORE: 0.4917

HELIX: 0.9624

FCONS_SCORE: 1.135

RIG_SCORE: 0.7456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2075M	TCGA-17-Z058	LUAD	TCGA	QKENL	DEG_APCC_KENBOX_2	0.0833
p.S2069L	TCGA-DX-A7EN	SARC	TCGA	QKENL	DEG_APCC_KENBOX_2	0.25
p.I2075V	DO228783	GACA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.0833
p.S2071L	DO220028	SARC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1944
p.E2058K	SIDM00527	Colorectal Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.2222
p.E2058K	ACH-000935	Colon/Colorectal Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	0.2222
p.E2058K	MDST8	large_intestine	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.2222
p.D2052V	SIDM00239	Kidney Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.0556
p.D2052V	OS-RC-2	kidney	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.0556
p.D2054V	OS-RC-2	kidney	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.1111
p.E2060K	MDST8	large_intestine	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15078	Centrosomal protein of 290 kDa	DEG_APCC_KENBOX_2	2062:2066	QKENL	APC,CDC20,FZR1	0.7619	More...
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	321:325	QKENL	APC,CDC20,FZR1	0.9617	More...
Q15643	Thyroid receptor-interacting protein 11	DEG_APCC_KENBOX_2	603:607	QKENL	APC,CDC20,FZR1	0.8324	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_APCC_KENBOX_2	874:878	QKENL	APC,CDC20,FZR1	0.9983	More...
Q3ZCT1	Zinc finger protein 260	DEG_APCC_KENBOX_2	203:207	QKENL	APC,CDC20,FZR1	0.7516	More...
Q9Y5G1	Protocadherin gamma-B3	DEG_APCC_KENBOX_2	182:186	QKENL	APC,CDC20,FZR1	0.9259	More...
Q9H7R5	Zinc finger protein 665	DEG_APCC_KENBOX_2	116:120	QKENL	APC,CDC20,FZR1	0.7555	More...
Q6NSI1	Putative ankyrin repeat domain-containing protein 26-like protein	DEG_APCC_KENBOX_2	204:208	QKENL	APC,CDC20,FZR1	0.9904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons