DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
QKENL
Uniprot ID:
O15078
Source protein:
Centrosomal protein of 290 kDa
Source gene:
CEP290
Class:
DEG_APCC_KENBOX_2
Location:
2062:2066
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7619
ASA_SCORE:
112.34
COIL:
0.0386
CONS_SCORE:
0.7521
DSS_SCORE:
0.4917
HELIX:
0.9624
FCONS_SCORE:
1.135
RIG_SCORE:
0.7456
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E2060K
MDST8
large_intestine
COSMIC
QKENL
DEG_APCC_KENBOX_2
0.2778
p.S2069L
TCGA-DX-A7EN
SARC
TCGA
QKENL
DEG_APCC_KENBOX_2
0.25
p.E2058K
SIDM00527
Colorectal Carcinoma
GDSC
QKENL
DEG_APCC_KENBOX_2
0.2222
p.E2058K
ACH-000935
Colon/Colorectal Cancer
CCLE
QKENL
DEG_APCC_KENBOX_2
0.2222
p.E2058K
MDST8
large_intestine
COSMIC
QKENL
DEG_APCC_KENBOX_2
0.2222
p.S2071L
DO220028
SARC
ICGC
QKENL
DEG_APCC_KENBOX_2
0.1944
p.D2054V
OS-RC-2
kidney
COSMIC
QKENL
DEG_APCC_KENBOX_2
0.1111
p.L2075M
TCGA-17-Z058
LUAD
TCGA
QKENL
DEG_APCC_KENBOX_2
0.0833
p.I2075V
DO228783
GACA
ICGC
QKENL
DEG_APCC_KENBOX_2
0.0833
p.D2052V
SIDM00239
Kidney Carcinoma
GDSC
QKENL
DEG_APCC_KENBOX_2
0.0556
p.D2052V
OS-RC-2
kidney
COSMIC
QKENL
DEG_APCC_KENBOX_2
0.0556
Showing 1 to 11 of 11 entries
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Drug responses associated with CEP290 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of QKENL
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13625
Apoptosis-stimulating of p53 protein 2
DEG_APCC_KENBOX_2
321:325
QKENL
APC,CDC20,FZR1
0.9617
More...
O15078
Centrosomal protein of 290 kDa
DEG_APCC_KENBOX_2
2062:2066
QKENL
APC,CDC20,FZR1
0.7619
More...
Q9Y5G1
Protocadherin gamma-B3
DEG_APCC_KENBOX_2
182:186
QKENL
APC,CDC20,FZR1
0.9259
More...
Q6NSI1
Putative ankyrin repeat domain-containing protein 26-like protein
DEG_APCC_KENBOX_2
204:208
QKENL
APC,CDC20,FZR1
0.9904
More...
Q15643
Thyroid receptor-interacting protein 11
DEG_APCC_KENBOX_2
603:607
QKENL
APC,CDC20,FZR1
0.8324
More...
Q9H2D6
TRIO and F-actin-binding protein
DEG_APCC_KENBOX_2
874:878
QKENL
APC,CDC20,FZR1
0.9983
More...
Q3ZCT1
Zinc finger protein 260
DEG_APCC_KENBOX_2
203:207
QKENL
APC,CDC20,FZR1
0.7516
More...
Q9H7R5
Zinc finger protein 665
DEG_APCC_KENBOX_2
116:120
QKENL
APC,CDC20,FZR1
0.7555
More...
Showing 1 to 8 of 8 entries
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