DegronMD - Q9H7R5(ZNF665)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R124S	TCGA-23-2081	OV	TCGA	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2222
p.G122R	TCGA-56-A49D	LUSC	TCGA	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.K110N	TCGA-85-8355	LUSC	TCGA	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation substituting flanking lysine	0.2778
p.L120R	TCGA-AP-A1DV	UCEC	TCGA	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.7316
p.A125P	TCGA-B9-4113	KIRP	TCGA	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1944
p.R129K	TCGA-BR-6456	STAD	TCGA	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.0833
p.R127C	TCGA-BS-A0TA	UCEC	TCGA	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1389
p.R127C	TCGA-FI-A2D5	UCEC	TCGA	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1389
p.L120P	TCGA-D9-A4Z6	SKCM	TCGA	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.6471
p.M114I	TCGA-DK-AA6U	BLCA	TCGA	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.H112Y	DO48524	BLCA	ICGC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2222
p.E117K	DO219010	BLCA	ICGC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.7022
p.R127W	DO231760	LINC	ICGC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1389
p.R127W	DO35406	PACA	ICGC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1389
p.R127W	DO43755	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1389
p.G110E	DO26587	LUSC	ICGC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation substituting flanking lysine	0.2778
p.P106L	DO220857	MELA	ICGC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.0556
p.N107Y	DO52151	PAEN	ICGC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.0833
p.D116N	DO37635	SKCM	ICGC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.6932
p.R127Q	DO42969	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.1389
p.S130R	DO42568	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.0556
p.M114T	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.M114T	SIDM00623	Other Blood Cancers	GDSC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2778
p.N119K	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.6918
p.N119K	ACH-000496	Lung Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.6918
p.N119K	NCI-H1792	lung	COSMIC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.6918
p.V112A	SIDM00836	Colorectal Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2222
p.V112A	ACH-000820	Colon/Colorectal Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2222
p.V112A	SW403	large intestine	COSMIC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2222
p.Q116P	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.5924
p.Q116P	ACH-000451	Lung Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.5924
p.Q116P	NCI-H2085	lung	COSMIC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.5924
p.Q124K	ACH-001861	Gallbladder Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2222
p.Q124K	TGBC1TKB	biliary tract	COSMIC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.2222
p.S130G	KYSE-140	oesophagus	COSMIC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation rewiring degron network	0.0556
p.G119D	NCI-H1651	lung	COSMIC	QKENL	DEG_APCC_KENBOX_2	116:120	Mutation altering degron motif	0.7198

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF665

UniProt ID: Q9H7R5

Entrez ID: 79788

Protein name: Zinc finger protein 665 (Zinc finger protein 160-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF665 in