DegronMD

Uniprot ID: Q9H7R5

Source protein: Zinc finger protein 665

Source gene: ZNF665

Class: DEG_APCC_KENBOX_2

Location: 116:120

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7555

ASA_SCORE: 101.76

COIL: 0.5428

CONS_SCORE: 0.356

DSS_SCORE: 0.4838

HELIX: 0.0216

FCONS_SCORE: 0.9733

RIG_SCORE: 0.7922

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R124S	TCGA-23-2081	OV	TCGA	QKENL	DEG_APCC_KENBOX_2	0.2222
p.G122R	TCGA-56-A49D	LUSC	TCGA	QKENL	DEG_APCC_KENBOX_2	0.2778
p.K110N	TCGA-85-8355	LUSC	TCGA	QKENL	DEG_APCC_KENBOX_2	0.2778
p.L120R	TCGA-AP-A1DV	UCEC	TCGA	QKENL	DEG_APCC_KENBOX_2	0.7316
p.A125P	TCGA-B9-4113	KIRP	TCGA	QKENL	DEG_APCC_KENBOX_2	0.1944
p.R129K	TCGA-BR-6456	STAD	TCGA	QKENL	DEG_APCC_KENBOX_2	0.0833
p.R127C	TCGA-BS-A0TA	UCEC	TCGA	QKENL	DEG_APCC_KENBOX_2	0.1389
p.R127C	TCGA-FI-A2D5	UCEC	TCGA	QKENL	DEG_APCC_KENBOX_2	0.1389
p.L120P	TCGA-D9-A4Z6	SKCM	TCGA	QKENL	DEG_APCC_KENBOX_2	0.6471
p.M114I	TCGA-DK-AA6U	BLCA	TCGA	QKENL	DEG_APCC_KENBOX_2	0.2778
p.H112Y	DO48524	BLCA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.2222
p.E117K	DO219010	BLCA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.7022
p.R127W	DO231760	LINC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1389
p.R127W	DO35406	PACA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1389
p.R127W	DO43755	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1389
p.G110E	DO26587	LUSC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.2778
p.P106L	DO220857	MELA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.0556
p.N107Y	DO52151	PAEN	ICGC	QKENL	DEG_APCC_KENBOX_2	0.0833
p.D116N	DO37635	SKCM	ICGC	QKENL	DEG_APCC_KENBOX_2	0.6932
p.R127Q	DO42969	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1389
p.S130R	DO42568	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.0556
p.M114T	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.2778
p.M114T	SIDM00623	Other Blood Cancers	GDSC	QKENL	DEG_APCC_KENBOX_2	0.2778
p.N119K	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.6918
p.N119K	ACH-000496	Lung Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	0.6918
p.N119K	NCI-H1792	lung	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.6918
p.V112A	SIDM00836	Colorectal Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.2222
p.V112A	ACH-000820	Colon/Colorectal Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	0.2222
p.V112A	SW403	large_intestine	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.2222
p.Q116P	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.5924
p.Q116P	ACH-000451	Lung Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	0.5924
p.Q116P	NCI-H2085	lung	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.5924
p.Q124K	ACH-001861	Gallbladder Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	0.2222
p.Q124K	TGBC1TKB	biliary_tract	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.2222
p.S130G	KYSE-140	oesophagus	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.0556
p.G119D	NCI-H1651	lung	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15078	Centrosomal protein of 290 kDa	DEG_APCC_KENBOX_2	2062:2066	QKENL	APC,CDC20,FZR1	0.7619	More...
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	321:325	QKENL	APC,CDC20,FZR1	0.9617	More...
Q15643	Thyroid receptor-interacting protein 11	DEG_APCC_KENBOX_2	603:607	QKENL	APC,CDC20,FZR1	0.8324	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_APCC_KENBOX_2	874:878	QKENL	APC,CDC20,FZR1	0.9983	More...
Q3ZCT1	Zinc finger protein 260	DEG_APCC_KENBOX_2	203:207	QKENL	APC,CDC20,FZR1	0.7516	More...
Q9Y5G1	Protocadherin gamma-B3	DEG_APCC_KENBOX_2	182:186	QKENL	APC,CDC20,FZR1	0.9259	More...
Q9H7R5	Zinc finger protein 665	DEG_APCC_KENBOX_2	116:120	QKENL	APC,CDC20,FZR1	0.7555	More...
Q6NSI1	Putative ankyrin repeat domain-containing protein 26-like protein	DEG_APCC_KENBOX_2	204:208	QKENL	APC,CDC20,FZR1	0.9904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QKENL

Degron related mutations and impact score

Drug responses associated with ZNF665 mutations

All proteins holding degron of QKENL