DegronMD

Uniprot ID: Q9H2D6

Source protein: TRIO and F-actin-binding protein

Source gene: TRIOBP

Class: DEG_APCC_KENBOX_2

Location: 874:878

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9983

ASA_SCORE: 122.14

COIL: 0.946

CONS_SCORE: 0.6693

DSS_SCORE: 0.6612

HELIX: 0.0426

FCONS_SCORE: 1.0564

RIG_SCORE: 0.6468

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E876D	TCGA-06-5416	GBM	TCGA	QKENL	DEG_APCC_KENBOX_2	0.6758
p.E876D	DO10880	GBM	ICGC	QKENL	DEG_APCC_KENBOX_2	0.6758
p.R885C	TCGA-44-2657	LUAD	TCGA	QKENL	DEG_APCC_KENBOX_2	0.1389
p.R885C	DO25020	LUAD	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1389
p.P883S	TCGA-A5-A0G2	UCEC	TCGA	QKENL	DEG_APCC_KENBOX_2	0.1944
p.P883S	DO41235	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1944
p.P883S	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.1944
p.P883S	ACH-002263	Esophageal Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	0.1944
p.P883S	KYSE-220	oesophagus	COSMIC	QKENL	DEG_APCC_KENBOX_2	0.1944
p.Q870E	TCGA-IQ-A61I	HNSC	TCGA	QKENL	DEG_APCC_KENBOX_2	0.2222
p.Q870E	DO49032	HNSC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.2222
p.T873I	DO222843	MELA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.75
p.S881A	SIDM01314	Colorectal Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15078	Centrosomal protein of 290 kDa	DEG_APCC_KENBOX_2	2062:2066	QKENL	APC,CDC20,FZR1	0.7619	More...
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	321:325	QKENL	APC,CDC20,FZR1	0.9617	More...
Q15643	Thyroid receptor-interacting protein 11	DEG_APCC_KENBOX_2	603:607	QKENL	APC,CDC20,FZR1	0.8324	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_APCC_KENBOX_2	874:878	QKENL	APC,CDC20,FZR1	0.9983	More...
Q3ZCT1	Zinc finger protein 260	DEG_APCC_KENBOX_2	203:207	QKENL	APC,CDC20,FZR1	0.7516	More...
Q9Y5G1	Protocadherin gamma-B3	DEG_APCC_KENBOX_2	182:186	QKENL	APC,CDC20,FZR1	0.9259	More...
Q9H7R5	Zinc finger protein 665	DEG_APCC_KENBOX_2	116:120	QKENL	APC,CDC20,FZR1	0.7555	More...
Q6NSI1	Putative ankyrin repeat domain-containing protein 26-like protein	DEG_APCC_KENBOX_2	204:208	QKENL	APC,CDC20,FZR1	0.9904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons