DegronMD - O15078(CEP290)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L2075M	TCGA-17-Z058	LUAD	TCGA	QKENL	DEG_APCC_KENBOX_2	2062:2066	Mutation rewiring degron network	0.0833
p.R1622C	TCGA-A5-A0G2	UCEC	TCGA	PTPVPT	DEG_SCF_FBW7_1	1611:1616	Mutation rewiring degron network	0.1667
p.R1622C	TCGA-EO-A22X	UCEC	TCGA	PTPVPT	DEG_SCF_FBW7_1	1611:1616	Mutation rewiring degron network	0.1667
p.S2069L	TCGA-DX-A7EN	SARC	TCGA	QKENL	DEG_APCC_KENBOX_2	2062:2066	Mutation rewiring degron network	0.25
p.R1624C	DO52706	CLLE	ICGC	PTPVPT	DEG_SCF_FBW7_1	1611:1616	Mutation rewiring degron network	0.1111
p.R1624C	DO43907	UCEC	ICGC	PTPVPT	DEG_SCF_FBW7_1	1611:1616	Mutation rewiring degron network	0.1111
p.R1624C	DO41235	UCEC	ICGC	PTPVPT	DEG_SCF_FBW7_1	1611:1616	Mutation rewiring degron network	0.1111
p.I2075V	DO228783	GACA	ICGC	QKENL	DEG_APCC_KENBOX_2	2062:2066	Mutation rewiring degron network	0.0833
p.S2071L	DO220028	SARC	ICGC	QKENL	DEG_APCC_KENBOX_2	2062:2066	Mutation rewiring degron network	0.1944
p.T1618I	DO229470	SKCA	ICGC	PTPVPT	DEG_SCF_FBW7_1	1611:1616	Mutation blocking ubiquitination signal	0.7222
p.E2058K	SIDM00527	Colorectal Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	2062:2066	Mutation rewiring degron network	0.2222
p.E2058K	ACH-000935	Colon/Colorectal Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	2062:2066	Mutation rewiring degron network	0.2222
p.E2058K	MDST8	large intestine	COSMIC	QKENL	DEG_APCC_KENBOX_2	2062:2066	Mutation rewiring degron network	0.2222
p.D2052V	SIDM00239	Kidney Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	2062:2066	Mutation rewiring degron network	0.0556
p.D2052V	OS-RC-2	kidney	COSMIC	QKENL	DEG_APCC_KENBOX_2	2062:2066	Mutation rewiring degron network	0.0556
p.V1614F	ACH-000944	Lymphoma	CCLE	PTPVPT	DEG_SCF_FBW7_1	1611:1616	Mutation altering degron motif	0.5957
p.D2054V	OS-RC-2	kidney	COSMIC	QKENL	DEG_APCC_KENBOX_2	2062:2066	Mutation rewiring degron network	0.1111
p.E2060K	MDST8	large intestine	COSMIC	QKENL	DEG_APCC_KENBOX_2	2062:2066	Mutation rewiring degron network	0.2778

Kaplan plot for CEP290 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP290

UniProt ID: O15078

Entrez ID: 80184

Protein name: Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP290 in