DegronMD

Uniprot ID: O15078

Source protein: Centrosomal protein of 290 kDa

Source gene: CEP290

Class: DEG_SCF_FBW7_1

Location: 1611:1616

E3 ligase: FBXW7

DEGRON score: 0.9178

ASA_SCORE: 95.9

COIL: 0.8327

CONS_SCORE: 0.5953

DSS_SCORE: 0.3964

HELIX: 0.1563

FCONS_SCORE: 0.8855

RIG_SCORE: 0.6696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1622C	TCGA-A5-A0G2	UCEC	TCGA	PTPVPT	DEG_SCF_FBW7_1	0.1667
p.R1622C	TCGA-EO-A22X	UCEC	TCGA	PTPVPT	DEG_SCF_FBW7_1	0.1667
p.R1624C	DO52706	CLLE	ICGC	PTPVPT	DEG_SCF_FBW7_1	0.1111
p.R1624C	DO43907	UCEC	ICGC	PTPVPT	DEG_SCF_FBW7_1	0.1111
p.R1624C	DO41235	UCEC	ICGC	PTPVPT	DEG_SCF_FBW7_1	0.1111
p.T1618I	DO229470	SKCA	ICGC	PTPVPT	DEG_SCF_FBW7_1	0.7222
p.V1614F	ACH-000944	Lymphoma	CCLE	PTPVPT	DEG_SCF_FBW7_1	0.5957

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15078	Centrosomal protein of 290 kDa	DEG_SCF_FBW7_1	1611:1616	PTPVPT	FBXW7	0.9178	More...
P59797	Selenoprotein V	DEG_SCF_FBW7_1	106:111	PTPVPT	FBXW7	0.9907	More...
H7BZ55	Ciliary rootlet coiled-coil protein 2	DEG_SCF_FBW7_1	55:60	PTPVPT	FBXW7	0.96	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons