DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PTPVPT
Uniprot ID:
P59797
Source protein:
Selenoprotein V
Source gene:
SELENOV
Class:
DEG_SCF_FBW7_1
Location:
106:111
E3 ligase:
FBXW7
DEGRON score:
0.9907
ASA_SCORE:
97.4333
COIL:
0.9775
CONS_SCORE:
0.6213
DSS_SCORE:
0.5233
HELIX:
0.007
FCONS_SCORE:
1.15
RIG_SCORE:
0.6374
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SELENOV mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPVPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15078
Centrosomal protein of 290 kDa
DEG_SCF_FBW7_1
1611:1616
PTPVPT
FBXW7
0.9178
More...
P59797
Selenoprotein V
DEG_SCF_FBW7_1
106:111
PTPVPT
FBXW7
0.9907
More...
H7BZ55
Ciliary rootlet coiled-coil protein 2
DEG_SCF_FBW7_1
55:60
PTPVPT
FBXW7
0.96
More...