DegronMD

Uniprot ID: Q15643

Source protein: Thyroid receptor-interacting protein 11

Source gene: TRIP11

Class: DEG_APCC_KENBOX_2

Location: 603:607

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8324

ASA_SCORE: 109.76

COIL: 0.0132

CONS_SCORE: 0.6545

DSS_SCORE: 0.4584

HELIX: 0.9862

FCONS_SCORE: 1.0103

RIG_SCORE: 0.7379

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L607V	TCGA-AG-A002	READ	TCGA	QKENL	DEG_APCC_KENBOX_2	0.5654
p.S601N	TCGA-XK-AAIW	PRAD	TCGA	QKENL	DEG_APCC_KENBOX_2	0.7222
p.S601N	DO51407	PRAD	ICGC	QKENL	DEG_APCC_KENBOX_2	0.7222
p.Q615L	DO231669	LINC	ICGC	QKENL	DEG_APCC_KENBOX_2	0.1111
p.S601G	DO229232	THCA	ICGC	QKENL	DEG_APCC_KENBOX_2	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15078	Centrosomal protein of 290 kDa	DEG_APCC_KENBOX_2	2062:2066	QKENL	APC,CDC20,FZR1	0.7619	More...
Q13625	Apoptosis-stimulating of p53 protein 2	DEG_APCC_KENBOX_2	321:325	QKENL	APC,CDC20,FZR1	0.9617	More...
Q15643	Thyroid receptor-interacting protein 11	DEG_APCC_KENBOX_2	603:607	QKENL	APC,CDC20,FZR1	0.8324	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_APCC_KENBOX_2	874:878	QKENL	APC,CDC20,FZR1	0.9983	More...
Q3ZCT1	Zinc finger protein 260	DEG_APCC_KENBOX_2	203:207	QKENL	APC,CDC20,FZR1	0.7516	More...
Q9Y5G1	Protocadherin gamma-B3	DEG_APCC_KENBOX_2	182:186	QKENL	APC,CDC20,FZR1	0.9259	More...
Q9H7R5	Zinc finger protein 665	DEG_APCC_KENBOX_2	116:120	QKENL	APC,CDC20,FZR1	0.7555	More...
Q6NSI1	Putative ankyrin repeat domain-containing protein 26-like protein	DEG_APCC_KENBOX_2	204:208	QKENL	APC,CDC20,FZR1	0.9904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons