DegronMD - Q9H2D6(TRIOBP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P354H	TCGA-06-1804	GBM	TCGA	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7694
p.P354H	DO12304	GBM	ICGC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7694
p.R816I	TCGA-06-5416	GBM	TCGA	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation rewiring degron network	0.1111
p.R816I	DO10880	GBM	ICGC	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation rewiring degron network	0.1111
p.E876D	TCGA-06-5416	GBM	TCGA	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation altering degron motif	0.6758
p.E876D	DO10880	GBM	ICGC	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation altering degron motif	0.6758
p.S978Y	TCGA-06-5416	GBM	TCGA	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation altering degron motif	0.712
p.S978Y	DO10880	GBM	ICGC	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation altering degron motif	0.712
p.S1153C	TCGA-09-2056	OV	TCGA	STESLVPSM	DEG_COP1_1	1143:1151	Mutation rewiring degron network	0.2778
p.S1153C	DO29228	OV	ICGC	STESLVPSM	DEG_COP1_1	1143:1151	Mutation rewiring degron network	0.2778
p.F1040L	TCGA-24-1427	OV	TCGA	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.1111
p.F1040L	DO28471	OV	ICGC	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.1111
p.R1930Q	TCGA-2L-AAQA	PAAD	TCGA	QRQALDYVE	DEG_APCC_DBOX_1	1939:1947	Mutation rewiring degron network	0.0833
p.R1930Q	DO51674	PAAD	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	1939:1947	Mutation rewiring degron network	0.0833
p.P1039R	TCGA-2Y-A9H3	LIHC	TCGA	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.1389
p.P1039R	DO219525	LIHC	ICGC	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.1389
p.Q1649H	TCGA-33-A5GW	LUSC	TCGA	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.0833
p.Q1649H	DO219122	LUSC	ICGC	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.0833
p.A259T	TCGA-43-2578	LUSC	TCGA	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.25
p.A259T	DO26662	LUSC	ICGC	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.25
p.R885C	TCGA-44-2657	LUAD	TCGA	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation rewiring degron network	0.1389
p.R885C	DO25020	LUAD	ICGC	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation rewiring degron network	0.1389
p.R940W	TCGA-49-AAR3	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.1389
p.R940W	DO218919	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.1389
p.P1029H	TCGA-98-8021	LUSC	TCGA	PPRY	ITCH	1029:1032	Mutation altering degron motif	0.7694
p.P1029H	DO27468	LUSC	ICGC	PPRY	ITCH	1029:1032	Mutation altering degron motif	0.7694
p.R816G	TCGA-A5-A0G1	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation rewiring degron network	0.1111
p.R816G	DO42472	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation rewiring degron network	0.1111
p.P883S	TCGA-A5-A0G2	UCEC	TCGA	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation rewiring degron network	0.1944
p.P883S	DO41235	UCEC	ICGC	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation rewiring degron network	0.1944
p.P883S	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation rewiring degron network	0.1944
p.P883S	ACH-002263	Esophageal Cancer	CCLE	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation rewiring degron network	0.1944
p.P883S	KYSE-220	oesophagus	COSMIC	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation rewiring degron network	0.1944
p.S1028L	TCGA-A5-A2K5	UCEC	TCGA	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.3056
p.S1028L	TCGA-AP-A1E0	UCEC	TCGA	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.3056
p.S1028L	TCGA-EE-A2MC	SKCM	TCGA	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.3056
p.S1028L	DO37559	SKCM	ICGC	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.3056
p.S1028L	DO43154	UCEC	ICGC	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.3056
p.S1028L	DO41379	UCEC	ICGC	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.3056
p.P2103L	TCGA-AA-3492	COAD	TCGA	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7582
p.P2103L	TCGA-BF-AAP7	SKCM	TCGA	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7582
p.P2103L	DO8224	COAD	ICGC	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7582
p.P2103L	DO219472	SKCM	ICGC	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7582
p.P2103L	SIDM00267	Biliary Tract Carcinoma	GDSC	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7582
p.P2103L	SIDM00054	Pancreatic Carcinoma	GDSC	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7582
p.P2103L	SIDM01464	Pancreatic Carcinoma	GDSC	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7582
p.P2103L	SIDM01435	Hepatocellular Carcinoma	GDSC	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7582
p.P2103L	TGBC24TKB	biliary tract	COSMIC	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7582
p.P2103L	PL18	pancreas	COSMIC	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7582
p.P1933H	TCGA-AA-3947	COAD	TCGA	QRQALDYVE	DEG_APCC_DBOX_1	1939:1947	Mutation rewiring degron network	0.1667
p.P1933H	DO8192	COAD	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	1939:1947	Mutation rewiring degron network	0.1667
p.R347Q	TCGA-AA-A00N	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.R347Q	TCGA-D3-A8GI	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.R347Q	DO9876	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.R347Q	DO222884	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.R347Q	DO50284	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1389
p.G966V	TCGA-AD-A5EJ	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.0556
p.G966V	DO50090	COAD	ICGC	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.0556
p.R1930W	TCGA-AJ-A3EL	UCEC	TCGA	QRQALDYVE	DEG_APCC_DBOX_1	1939:1947	Mutation rewiring degron network	0.0833
p.R1930W	DO41542	UCEC	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	1939:1947	Mutation rewiring degron network	0.0833
p.R1930W	DO42673	UCEC	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	1939:1947	Mutation rewiring degron network	0.0833
p.Q242H	TCGA-AP-A051	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0556
p.Q242H	DO42673	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0556
p.I2101T	TCGA-AX-A1C4	UCEC	TCGA	PPGY	ITCH	2102:2105	Mutation rewiring degron network	0.3056
p.I2101T	DO42480	UCEC	ICGC	PPGY	ITCH	2102:2105	Mutation rewiring degron network	0.3056
p.D789Y	TCGA-AZ-6600	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1389
p.D789Y	DO10774	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1389
p.R990Q	TCGA-B5-A1MR	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.0556
p.R990Q	TCGA-F5-6814	READ	TCGA	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.0556
p.R990Q	DO36556	READ	ICGC	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.0556
p.R990Q	DO41758	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.0556
p.S1648P	TCGA-B5-A1MR	UCEC	TCGA	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.0556
p.S1648P	DO41758	UCEC	ICGC	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.0556
p.P364A	TCGA-B8-5162	KIRC	TCGA	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation rewiring degron network	0.1944
p.P364A	TCGA-B8-5162	KIRC	TCGA	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1667
p.P364A	DO17197	KIRC	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation rewiring degron network	0.1944
p.P364A	DO17197	KIRC	ICGC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.1667
p.P373S	TCGA-BF-AAP1	SKCM	TCGA	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.6752
p.P373S	DO219464	SKCM	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.6752
p.P2103A	TCGA-BF-AAP7	SKCM	TCGA	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7503
p.P2103A	DO219472	SKCM	ICGC	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7503
p.P373T	TCGA-BP-5191	KIRC	TCGA	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.7031
p.P373T	DO19148	KIRC	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.7031
p.R825K	TCGA-CA-6717	COAD	TCGA	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation altering degron motif	0.6126
p.R825K	DO8264	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation altering degron motif	0.6126
p.A262T	TCGA-CC-5258	LIHC	TCGA	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1667
p.A262T	DO22881	LIHC	ICGC	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1667
p.V1652F	TCGA-CK-4951	COAD	TCGA	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1667
p.V1652F	DO10582	COAD	ICGC	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1667
p.D1893G	TCGA-D1-A17Q	UCEC	TCGA	NKENA	DEG_APCC_KENBOX_2	1901:1905	Mutation rewiring degron network	0.1111
p.D1893G	DO41903	UCEC	ICGC	NKENA	DEG_APCC_KENBOX_2	1901:1905	Mutation rewiring degron network	0.1111
p.R355K	TCGA-D3-A1Q4	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.6126
p.R355K	DO47631	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.6126
p.P910S	TCGA-D3-A5GL	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	919:923	Mutation rewiring degron network	0.0833
p.P910S	DO47430	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	919:923	Mutation rewiring degron network	0.0833
p.P824S	TCGA-D6-6516	HNSC	TCGA	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation altering degron motif	0.6752
p.P824S	DO15623	HNSC	ICGC	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation altering degron motif	0.6752
p.I2106F	TCGA-D7-A6EY	STAD	TCGA	PPGY	ITCH	2102:2105	Mutation rewiring degron network	0.3056
p.I2106F	DO50118	STAD	ICGC	PPGY	ITCH	2102:2105	Mutation rewiring degron network	0.3056
p.N784S	TCGA-DD-A1EE	LIHC	TCGA	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778
p.N784S	TCGA-EP-A26S	LIHC	TCGA	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778
p.N784S	DO22857	LIHC	ICGC	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778
p.N784S	DO22854	LIHC	ICGC	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778
p.A1891V	TCGA-DF-A2KU	UCEC	TCGA	NKENA	DEG_APCC_KENBOX_2	1901:1905	Mutation rewiring degron network	0.0556
p.A1891V	DO223286	UCEC	ICGC	NKENA	DEG_APCC_KENBOX_2	1901:1905	Mutation rewiring degron network	0.0556
p.T1660S	TCGA-DQ-5625	HNSC	TCGA	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation altering degron motif	0.6005
p.T1660S	DO15414	HNSC	ICGC	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation altering degron motif	0.6005
p.S782Y	TCGA-E6-A1LX	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.712
p.S782Y	DO41020	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.712
p.D1036N	TCGA-E6-A1LX	UCEC	TCGA	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.2222
p.D1036N	DO41020	UCEC	ICGC	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.2222
p.K1666N	TCGA-E6-A1LX	UCEC	TCGA	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation substituting flanking lysine	0.3333
p.K1666N	DO41020	UCEC	ICGC	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation substituting flanking lysine	0.3333
p.S1146N	TCGA-EA-A410	CESC	TCGA	STESLVPSM	DEG_COP1_1	1143:1151	Mutation altering degron motif	0.5958
p.S1146N	DO49929	CESC	ICGC	STESLVPSM	DEG_COP1_1	1143:1151	Mutation altering degron motif	0.5958
p.G944S	TCGA-EE-A29T	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.25
p.G944S	DO37742	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.25
p.P983S	TCGA-EE-A2MD	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.25
p.P983S	DO222434	MELA	ICGC	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.25
p.P983S	DO37851	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.25
p.P783L	TCGA-EE-A3JA	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.3056
p.P783L	DO47625	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.3056
p.Y2105C	TCGA-EE-A3JI	SKCM	TCGA	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7087
p.Y2105C	DO47268	SKCM	ICGC	PPGY	ITCH	2102:2105	Mutation altering degron motif	0.7087
p.R355I	TCGA-EO-A3B0	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.6991
p.R355I	TCGA-F5-6814	READ	TCGA	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.6991
p.R355I	DO229045	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.6991
p.R355I	DO36556	READ	ICGC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.6991
p.R355I	DO219773	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.6991
p.T266I	TCGA-EY-A215	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0556
p.T266I	DO42665	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0556
p.P369S	TCGA-FR-A726	SKCM	TCGA	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.6752
p.P369S	DO48665	SKCM	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.6752
p.E1145K	TCGA-FW-A3R5	SKCM	TCGA	STESLVPSM	DEG_COP1_1	1143:1151	Mutation altering degron motif	0.591
p.E1145K	DO37406	SKCM	ICGC	STESLVPSM	DEG_COP1_1	1143:1151	Mutation altering degron motif	0.591
p.R253Q	TCGA-GF-A6C9	SKCM	TCGA	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.6218
p.R253Q	DO51254	SKCM	ICGC	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.6218
p.R792K	TCGA-GN-A265	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.R792K	DO37491	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.A786V	TCGA-GN-A266	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.A786V	DO37432	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.Q870E	TCGA-IQ-A61I	HNSC	TCGA	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation rewiring degron network	0.2222
p.Q870E	TCGA-IQ-A61I	HNSC	TCGA	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.2778
p.Q870E	DO49032	HNSC	ICGC	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation rewiring degron network	0.2222
p.Q870E	DO49032	HNSC	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.2778
p.T356N	TCGA-LD-A74U	BRCA	TCGA	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7055
p.T356N	DO49025	BRCA	ICGC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation altering degron motif	0.7055
p.Q929E	TCGA-LL-A6FR	BRCA	TCGA	PRTSS	DEG_SPOP_SBC_1	919:923	Mutation rewiring degron network	0.1667
p.Q929E	DO50056	BRCA	ICGC	PRTSS	DEG_SPOP_SBC_1	919:923	Mutation rewiring degron network	0.1667
p.S828C	TCGA-NJ-A4YP	LUAD	TCGA	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation altering degron motif	0.8652
p.S828C	DO218943	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation altering degron motif	0.8652
p.S858F	TCGA-QB-A6FS	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.1667
p.S858F	DO219878	SKCA	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.1667
p.S858F	DO48654	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.1667
p.A938T	TCGA-VQ-A8P2	STAD	TCGA	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.0833
p.A938T	DO51761	STAD	ICGC	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.0833
p.A938T	SIDM00158	Glioblastoma	GDSC	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.0833
p.R379K	TCGA-VQ-A91K	STAD	TCGA	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation rewiring degron network	0.25
p.R379K	DO51785	STAD	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation rewiring degron network	0.25
p.G984S	TCGA-ZB-A966	THYM	TCGA	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.2222
p.S922C	TCGA-ZF-A9RG	BLCA	TCGA	PRTSS	DEG_SPOP_SBC_1	919:923	Mutation altering degron motif	0.7541
p.S922C	DO219076	BLCA	ICGC	PRTSS	DEG_SPOP_SBC_1	919:923	Mutation altering degron motif	0.7541
p.S922C	DO228471	BRCA	ICGC	PRTSS	DEG_SPOP_SBC_1	919:923	Mutation altering degron motif	0.7541
p.T372I	DO910	BOCA	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.7078
p.R375W	DO225285	BRCA	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.7523
p.R375W	DO227787	BRCA	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.7523
p.P1657T	DO230343	COCA	ICGC	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.3056
p.N863K	DO227709	COCA	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.3056
p.N863K	DO229010	COCA	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.3056
p.N863K	DO229013	COCA	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.3056
p.N863K	DO229016	COCA	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.3056
p.N863K	DO229003	COCA	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.3056
p.N863K	DO229005	COCA	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.3056
p.N863K	DO234205	ESAD	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.3056
p.N863K	DO230659	LAML	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.3056
p.N863K	DO231140	LAML	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.3056
p.R816K	DO222884	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation rewiring degron network	0.1111
p.T921I	DO50453	ESAD	ICGC	PRTSS	DEG_SPOP_SBC_1	919:923	Mutation altering degron motif	0.7078
p.L1948V	DO50387	ESAD	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	1939:1947	Mutation rewiring degron network	0.3056
p.P373H	DO233652	GACA	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.7694
p.L768I	DO233709	GACA	ICGC	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.S1027T	DO233731	GACA	ICGC	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.2778
p.A1905T	DO233882	GACA	ICGC	NKENA	DEG_APCC_KENBOX_2	1901:1905	Mutation altering degron motif	0.6028
p.R946M	DO233944	GACA	ICGC	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.3056
p.R940L	DO229034	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.1389
p.S1650I	DO229038	LICA	ICGC	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1111
p.D1899Y	DO229045	LICA	ICGC	NKENA	DEG_APCC_KENBOX_2	1901:1905	Mutation rewiring degron network	0.2778
p.R792T	DO229052	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.A259S	DO229006	LICA	ICGC	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.25
p.A1905S	DO50856	LICA	ICGC	NKENA	DEG_APCC_KENBOX_2	1901:1905	Mutation altering degron motif	0.6477
p.P1030S	DO231636	LINC	ICGC	PPRY	ITCH	1029:1032	Mutation altering degron motif	0.6752
p.H981R	DO231821	LINC	ICGC	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.3056
p.L1654Q	DO50785	LIRI	ICGC	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.2222
p.R1141M	DO224563	LUSC	ICGC	STESLVPSM	DEG_COP1_1	1143:1151	Mutation rewiring degron network	0.2778
p.P1039L	DO222880	MELA	ICGC	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.1389
p.Y1909C	DO222843	MELA	ICGC	NKENA	DEG_APCC_KENBOX_2	1901:1905	Mutation rewiring degron network	0.2222
p.T873I	DO222843	MELA	ICGC	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation blocking phosphorylation signal	0.75
p.T873I	DO222843	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation blocking phosphorylation signal	0.6389
p.R1934Q	DO50698	ORCA	ICGC	QRQALDYVE	DEG_APCC_DBOX_1	1939:1947	Mutation rewiring degron network	0.1944
p.D352N	DO232073	ORCA	ICGC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.2778
p.C1659R	DO49460	PACA	ICGC	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation altering degron motif	0.719
p.R2113C	DO232761	PBCA	ICGC	PPGY	ITCH	2102:2105	Mutation rewiring degron network	0.1111
p.R990G	DO47096	RECA	ICGC	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.0556
p.S979F	DO218900	SKCA	ICGC	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation altering degron motif	0.7982
p.S881A	SIDM01314	Colorectal Carcinoma	GDSC	QKENL	DEG_APCC_KENBOX_2	874:878	Mutation rewiring degron network	0.25
p.R926C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRTSS	DEG_SPOP_SBC_1	919:923	Mutation rewiring degron network	0.25
p.R926C	DND-41	haematopoietic and lymphoid tissue	COSMIC	PRTSS	DEG_SPOP_SBC_1	919:923	Mutation rewiring degron network	0.25
p.P864S	SIDM00545	Melanoma	GDSC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation altering degron motif	0.6752
p.P864S	Mewo	skin	COSMIC	PGTSS	DEG_SPOP_SBC_1	864:868	Mutation altering degron motif	0.6752
p.K1902T	SIDM01184	Bladder Carcinoma	GDSC	NKENA	DEG_APCC_KENBOX_2	1901:1905	Mutation altering degron motif	0.7306
p.K1902T	SIDM00964	Non-Cancerous	GDSC	NKENA	DEG_APCC_KENBOX_2	1901:1905	Mutation altering degron motif	0.7306
p.S1146R	SIDM00600	Thyroid Gland Carcinoma	GDSC	STESLVPSM	DEG_COP1_1	1143:1151	Mutation altering degron motif	0.6316
p.S1146R	ACH-001528	Thyroid Cancer	CCLE	STESLVPSM	DEG_COP1_1	1143:1151	Mutation altering degron motif	0.6316
p.S1146R	IHH-4	thyroid	COSMIC	STESLVPSM	DEG_COP1_1	1143:1151	Mutation altering degron motif	0.6316
p.C371F	SIDM00286	Neuroblastoma	GDSC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.5996
p.C371F	ACH-000136	Neuroblastoma	CCLE	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.5996
p.C371F	CHP-126	autonomic ganglia	COSMIC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation altering degron motif	0.5996
p.R1025G	SIDM00834	Colorectal Carcinoma	GDSC	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.2222
p.G984C	SIDM00282	Colorectal Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.2222
p.G984C	ACH-000998	Colon/Colorectal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.2222
p.G984C	CW-2	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.2222
p.I1667S	SIDM00965	Small Cell Lung Carcinoma	GDSC	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1944
p.I1667S	ACH-000800	Lung Cancer	CCLE	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1944
p.I1667S	NCI-H446	lung	COSMIC	ACTST	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1944
p.P952S	SIDM00140	Melanoma	GDSC	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.3056
p.P952S	ACH-000968	Skin Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.3056
p.P952S	COLO-792	skin	COSMIC	PQTSS	DEG_SPOP_SBC_1	947:951	Mutation rewiring degron network	0.3056
p.P1158L	SIDM00063	Melanoma	GDSC	STESLVPSM	DEG_COP1_1	1143:1151	Mutation rewiring degron network	0.1389
p.H1020R	SIDM00217	Colorectal Carcinoma	GDSC	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.0833
p.H1020R	ACH-000999	Colon/Colorectal Cancer	CCLE	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.0833
p.H1020R	SNU-1040	large intestine	COSMIC	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.0833
p.P378S	SIDM00256	Neuroblastoma	GDSC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation rewiring degron network	0.2778
p.G2099S	SIDM00359	Colorectal Carcinoma	GDSC	PPGY	ITCH	2102:2105	Mutation rewiring degron network	0.25
p.G2099S	ACH-000565	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	2102:2105	Mutation rewiring degron network	0.25
p.G2099S	RCM-1	large intestine	COSMIC	PPGY	ITCH	2102:2105	Mutation rewiring degron network	0.25
p.Y1032F	SIDM01608	Endometrial Carcinoma	GDSC	PPRY	ITCH	1029:1032	Mutation altering degron motif	0.7528
p.D265G	SIDM01617	Endometrial Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0833
p.D265G	ACH-000994	Endometrial/Uterine Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.0833
p.N822D	SIDM01566	Hodgkin's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation rewiring degron network	0.2778
p.I823N	SIDM01566	Hodgkin's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation rewiring degron network	0.3056
p.S367Y	SIDM01588	Endometrial Carcinoma	GDSC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation rewiring degron network	0.2778
p.S367Y	SIDM01588	Endometrial Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.0833
p.S367Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation rewiring degron network	0.2778
p.S367Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.0833
p.E2097G	ACH-000093	Pancreatic Cancer	CCLE	PPGY	ITCH	2102:2105	Mutation rewiring degron network	0.1944
p.E2097G	ACH-000364	Primary	CCLE	PPGY	ITCH	2102:2105	Mutation rewiring degron network	0.1944
p.E2097G	U-2-OS	bone	COSMIC	PPGY	ITCH	2102:2105	Mutation rewiring degron network	0.1944
p.G1932D	ACH-000971	Colon/Colorectal Cancer	CCLE	QRQALDYVE	DEG_APCC_DBOX_1	1939:1947	Mutation rewiring degron network	0.1389
p.L351V	ACH-001377	Pancreatic Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	354:358	Mutation rewiring degron network	0.25
p.E1903D	ACH-001416	Bladder Cancer	CCLE	NKENA	DEG_APCC_KENBOX_2	1901:1905	Mutation altering degron motif	0.6758
p.R912W	ACH-001523	Skin Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	919:923	Mutation rewiring degron network	0.1389
p.P1042Q	ACH-001652	Endometrial/Uterine Cancer	CCLE	PPRY	ITCH	1029:1032	Mutation rewiring degron network	0.0556
p.P1140H	ACH-001719	Ovarian Cancer	CCLE	STESLVPSM	DEG_COP1_1	1143:1151	Mutation rewiring degron network	0.25
p.R792S	ACH-001849	Bile Duct Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.S1150F	ACH-001982	Metastasis	CCLE	STESLVPSM	DEG_COP1_1	1143:1151	Mutation altering degron motif	0.7982
p.D832Y	ACH-001991	Primary	CCLE	PRSSS	DEG_SPOP_SBC_1	824:828	Mutation rewiring degron network	0.2222
p.E384G	U-2-OS	bone	COSMIC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation rewiring degron network	0.1111
p.G386S	RCM-1	large intestine	COSMIC	PTCTPQRE	DEG_SCF_FBW7_2	369:376	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIOBP

UniProt ID: Q9H2D6

Entrez ID: 11078

Protein name: TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIOBP in