DegronMD

Uniprot ID: Q9H2D6

Source protein: TRIO and F-actin-binding protein

Source gene: TRIOBP

Class: DEG_SCF_FBW7_2

Location: 369:376

E3 ligase: FBXW7

DEGRON score: 0.9883

ASA_SCORE: 111.0875

COIL: 0.9705

CONS_SCORE: 0.62

DSS_SCORE: 0.7533

HELIX: 0.0154

FCONS_SCORE: 1.0027

RIG_SCORE: 0.6264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P364A	TCGA-B8-5162	KIRC	TCGA	PTCTPQRE	DEG_SCF_FBW7_2	0.1944
p.P364A	DO17197	KIRC	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	0.1944
p.P373S	TCGA-BF-AAP1	SKCM	TCGA	PTCTPQRE	DEG_SCF_FBW7_2	0.6752
p.P373S	DO219464	SKCM	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	0.6752
p.P373T	TCGA-BP-5191	KIRC	TCGA	PTCTPQRE	DEG_SCF_FBW7_2	0.7031
p.P373T	DO19148	KIRC	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	0.7031
p.P369S	TCGA-FR-A726	SKCM	TCGA	PTCTPQRE	DEG_SCF_FBW7_2	0.6752
p.P369S	DO48665	SKCM	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	0.6752
p.R379K	TCGA-VQ-A91K	STAD	TCGA	PTCTPQRE	DEG_SCF_FBW7_2	0.25
p.R379K	DO51785	STAD	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	0.25
p.T372I	DO910	BOCA	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	0.7078
p.R375W	DO225285	BRCA	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	0.7523
p.R375W	DO227787	BRCA	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	0.7523
p.P373H	DO233652	GACA	ICGC	PTCTPQRE	DEG_SCF_FBW7_2	0.7694
p.C371F	SIDM00286	Neuroblastoma	GDSC	PTCTPQRE	DEG_SCF_FBW7_2	0.5996
p.C371F	ACH-000136	Neuroblastoma	CCLE	PTCTPQRE	DEG_SCF_FBW7_2	0.5996
p.C371F	CHP-126	autonomic_ganglia	COSMIC	PTCTPQRE	DEG_SCF_FBW7_2	0.5996
p.P378S	SIDM00256	Neuroblastoma	GDSC	PTCTPQRE	DEG_SCF_FBW7_2	0.2778
p.S367Y	SIDM01588	Endometrial Carcinoma	GDSC	PTCTPQRE	DEG_SCF_FBW7_2	0.2778
p.S367Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	PTCTPQRE	DEG_SCF_FBW7_2	0.2778
p.E384G	U-2-OS	bone	COSMIC	PTCTPQRE	DEG_SCF_FBW7_2	0.1111
p.G386S	RCM-1	large_intestine	COSMIC	PTCTPQRE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2D6	TRIO and F-actin-binding protein	DEG_SCF_FBW7_2	369:376	PTCTPQRE	FBXW7	0.9883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons