DegronMD

Uniprot ID: Q9H2D6

Source protein: TRIO and F-actin-binding protein

Source gene: TRIOBP

Class: DEG_SPOP_SBC_1

Location: 252:256

E3 ligase: SPOP

DEGRON score: 0.991

ASA_SCORE: 107.98

COIL: 0.9608

CONS_SCORE: 0.6642

DSS_SCORE: 0.8591

HELIX: 0.02

FCONS_SCORE: 1.0107

RIG_SCORE: 0.5343

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A259T	TCGA-43-2578	LUSC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.25
p.A259T	DO26662	LUSC	ICGC	PRSTT	DEG_SPOP_SBC_1	0.25
p.Q242H	TCGA-AP-A051	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.0556
p.Q242H	DO42673	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	0.0556
p.A262T	TCGA-CC-5258	LIHC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1667
p.A262T	DO22881	LIHC	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1667
p.T266I	TCGA-EY-A215	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.0556
p.T266I	DO42665	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	0.0556
p.R253Q	TCGA-GF-A6C9	SKCM	TCGA	PRSTT	DEG_SPOP_SBC_1	0.6218
p.R253Q	DO51254	SKCM	ICGC	PRSTT	DEG_SPOP_SBC_1	0.6218
p.A259S	DO229006	LICA	ICGC	PRSTT	DEG_SPOP_SBC_1	0.25
p.D265G	SIDM01617	Endometrial Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.0833
p.D265G	ACH-000994	Endometrial/Uterine Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01880	Immunoglobulin heavy constant delta	DEG_SPOP_SBC_1	329:333	PRSTT	SPOP	0.8106	More...
P78559	Microtubule-associated protein 1A	DEG_SPOP_SBC_1	2647:2651	PRSTT	SPOP	0.9396	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	588:592	PRSTT	SPOP	0.993	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1122:1126	PRSTT	SPOP	0.5437	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	252:256	PRSTT	SPOP	0.991	More...
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	DEG_SPOP_SBC_1	378:382	PRSTT	SPOP	0.8201	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons