DegronMD

Uniprot ID: Q06455

Source protein: Protein CBFA2T1

Source gene: RUNX1T1

Class: DEG_SPOP_SBC_1

Location: 588:592

E3 ligase: SPOP

DEGRON score: 0.993

ASA_SCORE: 105.58

COIL: 0.9534

CONS_SCORE: 0.5381

DSS_SCORE: 0.8517

HELIX: 0.0146

FCONS_SCORE: 1.1285

RIG_SCORE: 0.5581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P599L	TCGA-A5-AB3J	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1389
p.P599L	TCGA-AC-A8OP	BRCA	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1389
p.T582M	TCGA-AJ-A2QK	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1667
p.T598S	TCGA-CN-A63T	HNSC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1667
p.P595Q	TCGA-O2-A52S	LUSC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.6944
p.S580F	TCGA-W3-A825	SKCM	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1111
p.P593Q	ACH-000672	Lung Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	0.3056
p.T601P	ACH-000842	Colon/Colorectal Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	0.0833
p.M580I	ACH-000881	Skin Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	0.1111
p.M580I	MEL-JUSO	skin	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.1111
p.P579Q	ACH-000955	Colon/Colorectal Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	0.0833
p.P579Q	SNU-407	large_intestine	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.0833
p.T591A	ACH-000995	Leukemia	CCLE	PRSTT	DEG_SPOP_SBC_1	0.825
p.P583Q	ACH-000998	Colon/Colorectal Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	0.1944
p.E600G	ACH-001991	Primary	CCLE	PRSTT	DEG_SPOP_SBC_1	0.1111
p.M591I	MEL-JUSO	skin	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.7618
p.S578R	NCI-H1623	lung	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.0556
p.G588R	NCI-H187	lung	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.7568
p.P590Q	SNU-407	large_intestine	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.7035
p.E583K	Sarc9371	bone	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01880	Immunoglobulin heavy constant delta	DEG_SPOP_SBC_1	329:333	PRSTT	SPOP	0.8106	More...
P78559	Microtubule-associated protein 1A	DEG_SPOP_SBC_1	2647:2651	PRSTT	SPOP	0.9396	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	588:592	PRSTT	SPOP	0.993	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1122:1126	PRSTT	SPOP	0.5437	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	252:256	PRSTT	SPOP	0.991	More...
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	DEG_SPOP_SBC_1	378:382	PRSTT	SPOP	0.8201	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons