DegronMD

Uniprot ID: P01880

Source protein: Immunoglobulin heavy constant delta

Source gene: IGHD

Class: DEG_SPOP_SBC_1

Location: 329:333

E3 ligase: SPOP

DEGRON score: 0.8106

ASA_SCORE: 82.74

COIL: 0.8476

CONS_SCORE: 0.5793

DSS_SCORE: 0.4144

HELIX: 0.034

FCONS_SCORE: 1.1204

RIG_SCORE: 0.6882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P326L	TCGA-23-1124	OV	TCGA	PRSTT	DEG_SPOP_SBC_1	0.25
p.R341H	TCGA-26-5135	GBM	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1111
p.P322S	TCGA-27-1833	GBM	TCGA	PRSTT	DEG_SPOP_SBC_1	0.1389
p.P343Q	TCGA-EI-6507	READ	TCGA	PRSTT	DEG_SPOP_SBC_1	0.0556
p.A336V	TCGA-NH-A5IV	COAD	TCGA	PRSTT	DEG_SPOP_SBC_1	0.25
p.A335V	DO49095	COAD	ICGC	PRSTT	DEG_SPOP_SBC_1	0.2778
p.R340H	DO11447	GBM	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1389
p.P321S	DO12976	GBM	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1111
p.G329R	DO229346	LAML	ICGC	PRSTT	DEG_SPOP_SBC_1	0.7568
p.P324S	DO50970	LICA	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1944
p.P328R	DO220877	MELA	ICGC	PRSTT	DEG_SPOP_SBC_1	0.3056
p.R340C	DO46356	OV	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1389
p.R340C	DO34112	PACA	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1389
p.P325L	DO32596	OV	ICGC	PRSTT	DEG_SPOP_SBC_1	0.2222
p.P342Q	DO36675	READ	ICGC	PRSTT	DEG_SPOP_SBC_1	0.0833
p.V339A	SIDM00216	Colorectal Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.1667
p.T333M	SIDM01162	Kidney Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01880	Immunoglobulin heavy constant delta	DEG_SPOP_SBC_1	329:333	PRSTT	SPOP	0.8106	More...
P78559	Microtubule-associated protein 1A	DEG_SPOP_SBC_1	2647:2651	PRSTT	SPOP	0.9396	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	588:592	PRSTT	SPOP	0.993	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1122:1126	PRSTT	SPOP	0.5437	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	252:256	PRSTT	SPOP	0.991	More...
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	DEG_SPOP_SBC_1	378:382	PRSTT	SPOP	0.8201	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons