DegronMD

Uniprot ID: P78559

Source protein: Microtubule-associated protein 1A

Source gene: MAP1A

Class: DEG_SPOP_SBC_1

Location: 2647:2651

E3 ligase: SPOP

DEGRON score: 0.9396

ASA_SCORE: 101.66

COIL: 0.9074

CONS_SCORE: 0.5754

DSS_SCORE: 0.8557

HELIX: 0.0638

FCONS_SCORE: 0.9962

RIG_SCORE: 0.5448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2648H	TCGA-AJ-A8CW	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.7133
p.R2648H	DO233707	GACA	ICGC	PRSTT	DEG_SPOP_SBC_1	0.7133
p.R2648H	DO52400	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	0.7133
p.R2648C	TCGA-BG-A221	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	0.719
p.R2648C	DO42384	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	0.719
p.R2639L	DO228974	LICA	ICGC	PRSTT	DEG_SPOP_SBC_1	0.1111
p.T2655N	SIDM00377	Other Sarcomas	GDSC	PRSTT	DEG_SPOP_SBC_1	0.6667
p.T2655N	SKN	soft_tissue	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.6667
p.R2642Q	SIDM01199	Hepatocellular Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.1944
p.R2642Q	SNU-423	liver	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.1944
p.S2641F	SIDM00007	Other Solid Cancers	GDSC	PRSTT	DEG_SPOP_SBC_1	0.1667
p.S2641F	MCC13	skin	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.1667
p.A2637V	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	0.0556
p.A2637V	KYSE-140	oesophagus	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.0556
p.G2659D	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.1111
p.G2659D	JHH-4	liver	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.1111
p.T2643A	ONS-76	central_nervous_system	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.2222
p.T2643A	NCC021	kidney	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.2222
p.P2661S	SW13	adrenal_gland	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.0556
p.D2642H	JHH-7	liver	COSMIC	PRSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01880	Immunoglobulin heavy constant delta	DEG_SPOP_SBC_1	329:333	PRSTT	SPOP	0.8106	More...
P78559	Microtubule-associated protein 1A	DEG_SPOP_SBC_1	2647:2651	PRSTT	SPOP	0.9396	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	588:592	PRSTT	SPOP	0.993	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1122:1126	PRSTT	SPOP	0.5437	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	252:256	PRSTT	SPOP	0.991	More...
Q9HCU4	Cadherin EGF LAG seven-pass G-type receptor 2	DEG_SPOP_SBC_1	378:382	PRSTT	SPOP	0.8201	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons