DegronMD - Q6IQ55(TTBK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1162C	TCGA-5L-AAT0	BRCA	TCGA	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.719
p.R1162C	DO219593	BRCA	ICGC	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.719
p.R1162H	TCGA-A5-A1OF	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.7133
p.R1162H	DO227996	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.7133
p.R1162H	DO42568	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.7133
p.R1162H	SIDM00282	Colorectal Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.7133
p.R1162H	ACH-000998	Colon/Colorectal Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.7133
p.R1162H	CW-2	large intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.7133
p.T1069I	TCGA-AB-2826	LAML	TCGA	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation altering degron motif	0.7078
p.T1069I	DO21833	LAML	ICGC	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation altering degron motif	0.7078
p.S1070L	TCGA-AN-A046	BRCA	TCGA	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.3056
p.S1070L	TCGA-BR-8680	STAD	TCGA	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.3056
p.S1070L	DO1285	BRCA	ICGC	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.3056
p.S1070L	DO47769	STAD	ICGC	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.3056
p.S1119Y	TCGA-AP-A1DV	UCEC	TCGA	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.25
p.S1119Y	DO43186	UCEC	ICGC	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.25
p.S1119Y	SIDM01587	Bladder Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.25
p.S1119Y	ACH-000753	Bladder Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.25
p.D860G	TCGA-CK-4951	COAD	TCGA	IDPHVE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.6087
p.D860G	DO10582	COAD	ICGC	IDPHVE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.6087
p.R1173W	TCGA-CK-6751	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation rewiring degron network	0.1111
p.R1173W	DO10340	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation rewiring degron network	0.1111
p.S1058L	TCGA-D3-A2JE	SKCM	TCGA	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.1389
p.S1058L	DO219476	SKCM	ICGC	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.1389
p.S1130R	TCGA-DD-AADK	LIHC	TCGA	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1389
p.S1130R	TCGA-DD-AADK	LIHC	TCGA	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.2222
p.S1130R	DO52235	LIHC	ICGC	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1389
p.S1130R	DO52235	LIHC	ICGC	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.2222
p.S852L	TCGA-DK-A1A6	BLCA	TCGA	IDPHVE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1389
p.S852L	DO472	BLCA	ICGC	IDPHVE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1389
p.R857K	TCGA-DU-6407	LGG	TCGA	IDPHVE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.2778
p.R857K	DO22295	LGG	ICGC	IDPHVE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.2778
p.P1137L	TCGA-EO-A3B0	UCEC	TCGA	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation altering degron motif	0.6471
p.P1137L	DO219773	UCEC	ICGC	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation altering degron motif	0.6471
p.S1166F	TCGA-ER-A194	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	1155:1159	Mutation rewiring degron network	0.1389
p.S1166F	TCGA-ER-A194	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation rewiring degron network	0.3056
p.S1166F	DO47646	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	1155:1159	Mutation rewiring degron network	0.1389
p.S1166F	DO47646	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation rewiring degron network	0.3056
p.G850E	TCGA-FR-A3YO	SKCM	TCGA	IDPHVE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.0833
p.G850E	DO37419	SKCM	ICGC	IDPHVE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.0833
p.P1131L	TCGA-GF-A6C9	SKCM	TCGA	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1667
p.P1131L	TCGA-GF-A6C9	SKCM	TCGA	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1944
p.P1131L	DO51254	SKCM	ICGC	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1667
p.P1131L	DO51254	SKCM	ICGC	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.1944
p.P1151H	TCGA-VS-A9UB	CESC	TCGA	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1111
p.P1151H	TCGA-VS-A9UB	CESC	TCGA	PRSSS	DEG_SPOP_SBC_1	1155:1159	Mutation rewiring degron network	0.2222
p.P1151H	TCGA-VS-A9UB	CESC	TCGA	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation rewiring degron network	0.0556
p.P1151H	DO219731	CESC	ICGC	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1111
p.P1151H	DO219731	CESC	ICGC	PRSSS	DEG_SPOP_SBC_1	1155:1159	Mutation rewiring degron network	0.2222
p.P1151H	DO219731	CESC	ICGC	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation rewiring degron network	0.0556
p.D1063Y	DO48382	BLCA	ICGC	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.2778
p.W1059C	DO227802	COCA	ICGC	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.1667
p.I854V	DO227993	COCA	ICGC	IDPHVE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1944
p.R1123Q	DO233115	GACA	ICGC	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.6218
p.S1124R	DO233286	GACA	ICGC	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.7427
p.S1124G	DO228196	LICA	ICGC	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.6993
p.T1139K	DO228952	LICA	ICGC	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation altering degron motif	0.8417
p.P1079Q	DO229037	LICA	ICGC	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.0556
p.S1071F	DO45183	LIRI	ICGC	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.2778
p.P1122S	SIDM00845	Burkitt's Lymphoma	GDSC	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation altering degron motif	0.6752
p.P1140S	SIDM01483	Melanoma	GDSC	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation altering degron motif	0.6752
p.P1140S	ACH-000582	Skin Cancer	CCLE	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation altering degron motif	0.6752
p.P1140S	COLO-741	large intestine	COSMIC	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation altering degron motif	0.6752
p.R1148H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1944
p.R1148H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	1155:1159	Mutation rewiring degron network	0.1389
p.R1148H	ACH-002256	Leukemia	CCLE	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1944
p.R1148H	ACH-002256	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	1155:1159	Mutation rewiring degron network	0.1389
p.R1148H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1944
p.R1148H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	1155:1159	Mutation rewiring degron network	0.1389
p.T1062I	SIDM00211	B-Lymphoblastic Leukemia	GDSC	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.25
p.T1062I	SIDM01056	Breast Carcinoma	GDSC	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.25
p.T1163M	SIDM00457	Plasma Cell Myeloma	GDSC	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.7423
p.T1163M	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.7423
p.E872D	SIDM00118	Colorectal Carcinoma	GDSC	IDPHVE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1111
p.E872D	HCC2998	large intestine	COSMIC	IDPHVE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1111
p.Q1113H	SIDM01450	Gastric Carcinoma	GDSC	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.0833
p.Q1113H	ACH-000898	Gastric Cancer	CCLE	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.0833
p.S1152N	ACH-000961	Endometrial/Uterine Cancer	CCLE	PKTPPKS	DEG_SCF_FBW7_1	1137:1143	Mutation blocking phosphorylation signal	0.5278
p.S1152N	ACH-000961	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	1155:1159	Mutation blocking phosphorylation signal	0.6944
p.S1152N	ACH-000961	Endometrial/Uterine Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	1161:1165	Mutation blocking phosphorylation signal	0.5278
p.V1121L	OVCAR-8	ovary	COSMIC	PRSTT	DEG_SPOP_SBC_1	1122:1126	Mutation rewiring degron network	0.3056
p.A1063V	HT-3	cervix	COSMIC	VNSST	DEG_SPOP_SBC_1	1065:1069	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTBK2

UniProt ID: Q6IQ55

Entrez ID: 146057

Protein name: Tau-tubulin kinase 2 (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTBK2 in