DegronMD

Uniprot ID: Q6IQ55

Source protein: Tau-tubulin kinase 2

Source gene: TTBK2

Class: DEG_SPOP_SBC_1

Location: 1065:1069

E3 ligase: SPOP

DEGRON score: 0.9545

ASA_SCORE: 77.7

COIL: 0.8862

CONS_SCORE: 0.3702

DSS_SCORE: 0.5265

HELIX: 0.079

FCONS_SCORE: 0.8948

RIG_SCORE: 0.6306

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1069I	TCGA-AB-2826	LAML	TCGA	VNSST	DEG_SPOP_SBC_1	0.7078
p.T1069I	DO21833	LAML	ICGC	VNSST	DEG_SPOP_SBC_1	0.7078
p.S1070L	TCGA-AN-A046	BRCA	TCGA	VNSST	DEG_SPOP_SBC_1	0.3056
p.S1070L	TCGA-BR-8680	STAD	TCGA	VNSST	DEG_SPOP_SBC_1	0.3056
p.S1070L	DO1285	BRCA	ICGC	VNSST	DEG_SPOP_SBC_1	0.3056
p.S1070L	DO47769	STAD	ICGC	VNSST	DEG_SPOP_SBC_1	0.3056
p.S1058L	TCGA-D3-A2JE	SKCM	TCGA	VNSST	DEG_SPOP_SBC_1	0.1389
p.S1058L	DO219476	SKCM	ICGC	VNSST	DEG_SPOP_SBC_1	0.1389
p.D1063Y	DO48382	BLCA	ICGC	VNSST	DEG_SPOP_SBC_1	0.2778
p.W1059C	DO227802	COCA	ICGC	VNSST	DEG_SPOP_SBC_1	0.1667
p.P1079Q	DO229037	LICA	ICGC	VNSST	DEG_SPOP_SBC_1	0.0556
p.S1071F	DO45183	LIRI	ICGC	VNSST	DEG_SPOP_SBC_1	0.2778
p.T1062I	SIDM00211	B-Lymphoblastic Leukemia	GDSC	VNSST	DEG_SPOP_SBC_1	0.25
p.T1062I	SIDM01056	Breast Carcinoma	GDSC	VNSST	DEG_SPOP_SBC_1	0.25
p.A1063V	HT-3	cervix	COSMIC	VNSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15234	Protein CASC3	DEG_SPOP_SBC_1	123:127	VNSST	SPOP	0.9752	More...
O75044	SLIT-ROBO Rho GTPase-activating protein 2	DEG_SPOP_SBC_1	1056:1060	VNSST	SPOP	0.9566	More...
P82094	TATA element modulatory factor	DEG_SPOP_SBC_1	360:364	VNSST	SPOP	0.9561	More...
Q16181	Septin-7	DEG_SPOP_SBC_1	15:19	VNSST	SPOP	0.6742	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1065:1069	VNSST	SPOP	0.9545	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons