DegronMD

Uniprot ID: O75044

Source protein: SLIT-ROBO Rho GTPase-activating protein 2

Source gene: SRGAP2

Class: DEG_SPOP_SBC_1

Location: 1056:1060

E3 ligase: SPOP

DEGRON score: 0.9566

ASA_SCORE: 94.88

COIL: 0.958

CONS_SCORE: 0.2489

DSS_SCORE: 0.6536

HELIX: 0.017

FCONS_SCORE: 0.931

RIG_SCORE: 0.57

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1062A	SIDM02044	Colorectal Carcinoma	GDSC	VNSST	DEG_SPOP_SBC_1	0.2778
p.P1047S	SIDM00045	Gastric Carcinoma	GDSC	VNSST	DEG_SPOP_SBC_1	0.0833
p.P1047S	HSC-39	stomach	COSMIC	VNSST	DEG_SPOP_SBC_1	0.0833
p.P1046S	HSC-39	stomach	COSMIC	VNSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15234	Protein CASC3	DEG_SPOP_SBC_1	123:127	VNSST	SPOP	0.9752	More...
O75044	SLIT-ROBO Rho GTPase-activating protein 2	DEG_SPOP_SBC_1	1056:1060	VNSST	SPOP	0.9566	More...
P82094	TATA element modulatory factor	DEG_SPOP_SBC_1	360:364	VNSST	SPOP	0.9561	More...
Q16181	Septin-7	DEG_SPOP_SBC_1	15:19	VNSST	SPOP	0.6742	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1065:1069	VNSST	SPOP	0.9545	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons