DegronMD - O15234(CASC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E118K	TCGA-44-2659	LUAD	TCGA	VNSST	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1944
p.E118K	DO23744	LUAD	ICGC	VNSST	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1944
p.D175A	TCGA-B5-A0JU	UCEC	TCGA	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0833
p.D175A	DO40819	UCEC	ICGC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0833
p.K177N	TCGA-B5-A0JY	UCEC	TCGA	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation blocking ubiquitination signal	0.5833
p.K177N	DO43041	UCEC	ICGC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation blocking ubiquitination signal	0.5833
p.Y635H	TCGA-DI-A1BU	UCEC	TCGA	LAPTYFSAPGVMNF	DEG_ODPH_VHL_1	617:630	Mutation rewiring degron network	0.1944
p.Y635H	DO42023	UCEC	ICGC	LAPTYFSAPGVMNF	DEG_ODPH_VHL_1	617:630	Mutation rewiring degron network	0.1944
p.D175N	TCGA-DK-A2I4	BLCA	TCGA	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0833
p.D175N	DO465	BLCA	ICGC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0833
p.P611L	DO222905	BTCA	ICGC	LAPTYFSAPGVMNF	DEG_ODPH_VHL_1	617:630	Mutation rewiring degron network	0.1667
p.R184Q	DO233791	GACA	ICGC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.7329
p.R184Q	DO233882	GACA	ICGC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.7329
p.R184Q	SIDM00217	Colorectal Carcinoma	GDSC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.7329
p.R184Q	ACH-000999	Colon/Colorectal Cancer	CCLE	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.7329
p.R184Q	SNU-1040	large intestine	COSMIC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.7329
p.D121Y	DO229027	LICA	ICGC	VNSST	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.2778
p.G609E	DO222536	MELA	ICGC	LAPTYFSAPGVMNF	DEG_ODPH_VHL_1	617:630	Mutation rewiring degron network	0.1111
p.R176W	SIDM00205	Ewing's Sarcoma	GDSC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.1111
p.R176W	ACH-002110	Bone Cancer	CCLE	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.1111
p.R176W	EW-1	bone	COSMIC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.1111

Kaplan plot for CASC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASC3

UniProt ID: O15234

Entrez ID: 22794

Protein name: Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CASC3 in