DegronMD

Uniprot ID: O15234

Source protein: Protein CASC3

Source gene: CASC3

Class: LIG_APCC_ABBAyCdc20_2

Location: 184:190

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9226

ASA_SCORE: 72.3286

COIL: 0.5827

CONS_SCORE: 0.6909

DSS_SCORE: 0.5249

HELIX: 0.1531

FCONS_SCORE: 1.0223

RIG_SCORE: 0.7438

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D175A	TCGA-B5-A0JU	UCEC	TCGA	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D175A	DO40819	UCEC	ICGC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.0833
p.K177N	TCGA-B5-A0JY	UCEC	TCGA	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.5833
p.K177N	DO43041	UCEC	ICGC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.5833
p.D175N	TCGA-DK-A2I4	BLCA	TCGA	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D175N	DO465	BLCA	ICGC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R184Q	DO233791	GACA	ICGC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R184Q	DO233882	GACA	ICGC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R184Q	SIDM00217	Colorectal Carcinoma	GDSC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R184Q	ACH-000999	Colon/Colorectal Cancer	CCLE	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R184Q	SNU-1040	large_intestine	COSMIC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R176W	SIDM00205	Ewing's Sarcoma	GDSC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R176W	ACH-002110	Bone Cancer	CCLE	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R176W	EW-1	bone	COSMIC	RKGLFFE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15234	Protein CASC3	LIG_APCC_ABBAyCdc20_2	184:190	RKGLFFE	APC,CDC20,FZR1	0.9226	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons