DegronMD

Uniprot ID: O15234

Source protein: Protein CASC3

Source gene: CASC3

Class: DEG_ODPH_VHL_1

Location: 617:630

E3 ligase: VHL

DEGRON score: 0.7145

ASA_SCORE: 43.5357

COIL: 0.8335

CONS_SCORE: 0.459

DSS_SCORE: 0.4185

HELIX: 0.0314

FCONS_SCORE: 0.9853

RIG_SCORE: 0.6954

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y635H	TCGA-DI-A1BU	UCEC	TCGA	LAPTYFSAPGVMNF	DEG_ODPH_VHL_1	0.1944
p.Y635H	DO42023	UCEC	ICGC	LAPTYFSAPGVMNF	DEG_ODPH_VHL_1	0.1944
p.P611L	DO222905	BTCA	ICGC	LAPTYFSAPGVMNF	DEG_ODPH_VHL_1	0.1667
p.G609E	DO222536	MELA	ICGC	LAPTYFSAPGVMNF	DEG_ODPH_VHL_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15234	Protein CASC3	DEG_ODPH_VHL_1	617:630	LAPTYFSAPGVMNF	VHL	0.7145	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons