DegronMD

Uniprot ID: O15234

Source protein: Protein CASC3

Source gene: CASC3

Class: DEG_SPOP_SBC_1

Location: 123:127

E3 ligase: SPOP

DEGRON score: 0.9752

ASA_SCORE: 90.2

COIL: 0.747

CONS_SCORE: 0.4012

DSS_SCORE: 0.7

HELIX: 0.214

FCONS_SCORE: 1.001

RIG_SCORE: 0.6188

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E118K	TCGA-44-2659	LUAD	TCGA	VNSST	DEG_SPOP_SBC_1	0.1944
p.E118K	DO23744	LUAD	ICGC	VNSST	DEG_SPOP_SBC_1	0.1944
p.D121Y	DO229027	LICA	ICGC	VNSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15234	Protein CASC3	DEG_SPOP_SBC_1	123:127	VNSST	SPOP	0.9752	More...
O75044	SLIT-ROBO Rho GTPase-activating protein 2	DEG_SPOP_SBC_1	1056:1060	VNSST	SPOP	0.9566	More...
P82094	TATA element modulatory factor	DEG_SPOP_SBC_1	360:364	VNSST	SPOP	0.9561	More...
Q16181	Septin-7	DEG_SPOP_SBC_1	15:19	VNSST	SPOP	0.6742	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1065:1069	VNSST	SPOP	0.9545	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons