DegronMD

Uniprot ID: P82094

Source protein: TATA element modulatory factor

Source gene: TMF1

Class: DEG_SPOP_SBC_1

Location: 360:364

E3 ligase: SPOP

DEGRON score: 0.9561

ASA_SCORE: 91.88

COIL: 0.912

CONS_SCORE: 0.3011

DSS_SCORE: 0.3784

HELIX: 0.0176

FCONS_SCORE: 0.9407

RIG_SCORE: 0.7091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N361H	TCGA-CA-6717	COAD	TCGA	VNSST	DEG_SPOP_SBC_1	0.6312
p.N361H	DO8264	COAD	ICGC	VNSST	DEG_SPOP_SBC_1	0.6312
p.A373T	TCGA-D8-A1JA	BRCA	TCGA	VNSST	DEG_SPOP_SBC_1	0.0833
p.A373T	DO2819	BRCA	ICGC	VNSST	DEG_SPOP_SBC_1	0.0833
p.S363L	TCGA-VS-A958	CESC	TCGA	VNSST	DEG_SPOP_SBC_1	0.7667
p.S363L	DO51639	CESC	ICGC	VNSST	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15234	Protein CASC3	DEG_SPOP_SBC_1	123:127	VNSST	SPOP	0.9752	More...
O75044	SLIT-ROBO Rho GTPase-activating protein 2	DEG_SPOP_SBC_1	1056:1060	VNSST	SPOP	0.9566	More...
P82094	TATA element modulatory factor	DEG_SPOP_SBC_1	360:364	VNSST	SPOP	0.9561	More...
Q16181	Septin-7	DEG_SPOP_SBC_1	15:19	VNSST	SPOP	0.6742	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1065:1069	VNSST	SPOP	0.9545	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons