DegronMD - P82094(TMF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K922R	TCGA-06-2559	GBM	TCGA	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation substituting flanking lysine	0.3333
p.K922R	DO12610	GBM	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation substituting flanking lysine	0.3333
p.T191A	TCGA-17-Z044	LUAD	TCGA	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.7139
p.S925Y	TCGA-39-5031	LUSC	TCGA	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation blocking phosphorylation signal	0.75
p.S925Y	DO26526	LUSC	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation blocking phosphorylation signal	0.75
p.T768I	TCGA-96-A4JK	LUSC	TCGA	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation altering degron motif	0.5966
p.T768I	DO45442	LUSC	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation altering degron motif	0.5966
p.Q779H	TCGA-A5-A0G1	UCEC	TCGA	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.25
p.Q779H	DO42472	UCEC	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.25
p.I201T	TCGA-AJ-A3BG	UCEC	TCGA	ESDMKVPTV	DEG_COP1_1	184:192	Mutation rewiring degron network	0.0833
p.I201T	DO42633	UCEC	ICGC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation rewiring degron network	0.0833
p.E178K	TCGA-AP-A056	UCEC	TCGA	ESDMKVPTV	DEG_COP1_1	184:192	Mutation rewiring degron network	0.1667
p.E178K	TCGA-AP-A056	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1111
p.E178K	DO43971	UCEC	ICGC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation rewiring degron network	0.1667
p.E178K	DO43971	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1111
p.N418D	TCGA-AP-A059	UCEC	TCGA	VSSTPINE	DEG_SCF_FBW7_2	412:419	Mutation altering degron motif	0.5821
p.N418D	DO41361	UCEC	ICGC	VSSTPINE	DEG_SCF_FBW7_2	412:419	Mutation altering degron motif	0.5821
p.E179D	TCGA-B5-A3FC	UCEC	TCGA	ESDMKVPTV	DEG_COP1_1	184:192	Mutation rewiring degron network	0.1944
p.E179D	TCGA-B5-A3FC	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.E179D	DO41871	UCEC	ICGC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation rewiring degron network	0.1944
p.E179D	DO41871	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.E419K	TCGA-C5-A8XJ	CESC	TCGA	VSSTPINE	DEG_SCF_FBW7_2	412:419	Mutation altering degron motif	0.7022
p.E419K	DO49902	CESC	ICGC	VSSTPINE	DEG_SCF_FBW7_2	412:419	Mutation altering degron motif	0.7022
p.N361H	TCGA-CA-6717	COAD	TCGA	VNSST	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.6312
p.N361H	DO8264	COAD	ICGC	VNSST	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.6312
p.V941I	TCGA-D7-6527	STAD	TCGA	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.1111
p.V941I	DO38635	STAD	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.1111
p.G167S	TCGA-D7-A748	STAD	TCGA	AGTSS	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.5882
p.G167S	DO50122	STAD	ICGC	AGTSS	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.5882
p.A373T	TCGA-D8-A1JA	BRCA	TCGA	VNSST	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0833
p.A373T	DO2819	BRCA	ICGC	VNSST	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0833
p.R934H	TCGA-DU-6392	LGG	TCGA	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.3056
p.R934H	DO230346	COCA	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.3056
p.R934H	DO22237	LGG	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.3056
p.R934H	DO232761	PBCA	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.3056
p.S761G	TCGA-E6-A1LX	UCEC	TCGA	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.1389
p.S761G	DO41020	UCEC	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.1389
p.S160L	TCGA-FW-A5DY	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	166:170	Mutation blocking phosphorylation signal	0.6111
p.S160L	DO47257	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	166:170	Mutation blocking phosphorylation signal	0.6111
p.M187V	TCGA-GV-A3QH	BLCA	TCGA	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.6097
p.M187V	DO464	BLCA	ICGC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.6097
p.M187V	SIDM00591	Oral Cavity Carcinoma	GDSC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.6097
p.S185L	TCGA-VQ-A8PE	STAD	TCGA	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.6556
p.S185L	DO222572	MELA	ICGC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.6556
p.S185L	DO51769	STAD	ICGC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.6556
p.S363L	TCGA-VS-A958	CESC	TCGA	VNSST	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.7667
p.S363L	DO51639	CESC	ICGC	VNSST	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.7667
p.R934C	TCGA-ZX-AA5X	CESC	TCGA	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.3056
p.R934C	DO219762	CESC	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.3056
p.R934C	DO230343	COCA	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.3056
p.E198K	DO225117	BRCA	ICGC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation rewiring degron network	0.1667
p.E198K	DO227878	BRCA	ICGC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation rewiring degron network	0.1667
p.Q782K	DO230343	COCA	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.1667
p.R759Q	DO230659	LAML	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.0833
p.R759Q	DO231140	LAML	ICGC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.0833
p.R759Q	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.0833
p.R759Q	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.0833
p.R759Q	SIDM01551	Gastric Carcinoma	GDSC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.0833
p.R759Q	SIDM01451	Pancreatic Carcinoma	GDSC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.0833
p.S927Y	DO228974	LICA	ICGC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation altering degron motif	0.712
p.P408T	DO229035	LICA	ICGC	VSSTPINE	DEG_SCF_FBW7_2	412:419	Mutation rewiring degron network	0.2222
p.V192L	DO228349	MALY	ICGC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.5654
p.V192L	SIDM00656	Burkitt's Lymphoma	GDSC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.5654
p.V192L	SIDM00641	Burkitt's Lymphoma	GDSC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.5654
p.V192L	ACH-000944	Lymphoma	CCLE	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.5654
p.V192L	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	ESDMKVPTV	DEG_COP1_1	184:192	Mutation altering degron motif	0.5654
p.V403A	DO232761	PBCA	ICGC	VSSTPINE	DEG_SCF_FBW7_2	412:419	Mutation rewiring degron network	0.0833
p.S930C	SIDM00473	Oral Cavity Carcinoma	GDSC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation altering degron motif	0.7541
p.S930C	PE/CA-PJ15	upper aerodigestive tract	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation altering degron motif	0.7541
p.K922N	SIDM00215	Colorectal Carcinoma	GDSC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation substituting flanking lysine	0.3333
p.K922N	SNU-283	large intestine	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation substituting flanking lysine	0.3333
p.S936P	SIDM00220	Ovarian Carcinoma	GDSC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.25
p.S936P	OC-314	ovary	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.25
p.R924H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.2778
p.R924H	RS4-11	haematopoietic and lymphoid tissue	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.2778
p.S927C	ACH-000619	Head and Neck Cancer	CCLE	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation altering degron motif	0.7541
p.S927C	PE/CA-PJ15	upper aerodigestive tract	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation altering degron motif	0.7541
p.R921H	ACH-000874	Leukemia	CCLE	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.1944
p.R921H	RS4-11	haematopoietic and lymphoid tissue	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation rewiring degron network	0.1944
p.S933P	ACH-000962	Ovarian Cancer	CCLE	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation altering degron motif	0.7863
p.S933P	ACH-001145	Ovarian Cancer	CCLE	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation altering degron motif	0.7863
p.S933P	OC-314	ovary	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation altering degron motif	0.7863
p.K919N	SNU-283	large intestine	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation substituting flanking lysine	0.25
p.L765I	CW-2	large intestine	COSMIC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation rewiring degron network	0.25
p.E929K	KYSE-410	oesophagus	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation altering degron motif	0.7022
p.E929K	DIFI	large intestine	COSMIC	VSSTPTMS	DEG_SCF_FBW7_1	926:933	Mutation altering degron motif	0.7022
p.E768G	EN	endometrium	COSMIC	TRPLLRQIE	DEG_APCC_DBOX_1	768:776	Mutation altering degron motif	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMF1

UniProt ID: P82094

Entrez ID: 7110

Protein name: TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMF1 in